Evidence map›Paper›PMID 42643595›Full record

ArticleJournal of the Endocrine Society2026

The role of insurance status in molecular testing for thyroid nodules with indeterminate cytology.

Kelvin Memeh, Daniel Chopyk, Bryan An, Stephanie Paras, Harold W Davis, Vennila Padmanaban, Barbra S Miller, John E Phay, Bridget A Oppong, Jesse J Plascak and 3 more

Abstract read
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kelvin MemehDivision of Surgical Oncology, Department of Surgery, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID https://orcid.org/0000-0001-7385-577X
Daniel ChopykDivision of Surgical Oncology, Department of Surgery, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Bryan AnThe Ohio State University College of Medicine, Columbus, OH 43210, USA.
Stephanie ParasThe Ohio State University College of Medicine, Columbus, OH 43210, USA.
Harold W DavisDivision of Surgical Oncology, Department of Surgery, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Vennila PadmanabanDivision of Surgical Oncology, Department of Surgery, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Barbra S MillerDivision of Surgical Oncology, Department of Surgery, University of Arizona College of Medicine, Tucson, AZ 85721, USA.
John E PhayDivision of Surgical Oncology, Department of Surgery, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID https://orcid.org/0000-0002-8482-2137
Bridget A OppongDivision of Surgical Oncology, Department of Surgery, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Jesse J PlascakThe Division of Cancer Prevention and Control, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH 43210, USA.
Caitlin E HackettDepartment of Radiology, Ohio State University Wexner Medical, Columbus, OH 43210, USA.ORCID https://orcid.org/0009-0004-8074-1374
Samantha M RuffDivision of Surgical Oncology, Department of Surgery, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.ORCID https://orcid.org/0000-0001-5275-6705
Priya H DedhiaDivision of Surgical Oncology, Department of Surgery, Ohio State University Comprehensive Cancer Center and Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The aim of the study was to evaluate the effect of health insurance status on rate of molecular testing (MT) and subsequent thyroidectomy in patients with indeterminate thyroid nodules in a real-world high-volume clinical setting. Methods: This is a single-center, retrospective study of patients who underwent fine-needle aspiration and had Bethesda III-IV cytology results between 2014 and 2022. We excluded patients with prior thyroid cancer, thyroidectomy, or incomplete insurance data. We utilized multivariable logistic regression to identify significant predictors of MT utilization and surgical intervention; specifically examining the role of insurance status and clinical symptoms. Results: A total of 448 patients were included (median age: 52 years, 79% women) with 79% of patients undergoing MT; with an associated 27-percentage-point (34% vs 61%, Conclusion: Despite high MT penetration at an academic medical center, lack of health insurance poses a critical barrier to evidence-based risk stratification leading to higher rates of diagnostic lobectomy. While symptoms appropriately drove surgical management, expanding affordable MT access may mitigate barriers to care for patients with thyroid nodules.

Indexed as

barriers to careBethesda categorymolecular testingthyroid cancerthyroid noduleuninsured

Identifiers

PMID42643595
PMCPMC13504264

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.