SynthesisFrontiers in immunology2026
Celiac disease and the gut microbiota: bibliometric mapping of research hotspots and immune-mechanistic trends.
Synthesis in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Celiac disease (CeD) is a chronic gluten-triggered immune-mediated enteropathy. Increasing evidence suggests that the gut microbiota may contribute to CeD pathophysiology. However, the global research landscape, hotspot evolution, and immune-mechanistic trends in CeD-gut microbiota research remain insufficiently mapped. This study aimed to systematically map the current research landscape and future hotspots in CeD-gut microbiota research. Methods: We conducted a bibliometric analysis with a mechanism-oriented narrative interpretation. Literature related to CeD and the gut microbiota was retrieved from the Web of Science Core Collection (WoSCC) and PubMed through April 25, 2026, without a lower publication-year restriction (the earliest eligible record was published in 2005). A total of 265 WoSCC records constituted the primary bibliometric dataset, while 320 PubMed records were analyzed separately for cross-database sensitivity comparison. CiteSpace, VOSviewer, and Bibliometrix were used to analyze publication trends, journals, authors, countries or regions, institutions, co-citation structures, keywords, and burst terms. Results: Annual publication output showed an overall upward trend in CeD-gut microbiota research, indicating sustained academic attention to this field. Core journal distribution suggested that this research area spans nutrition, microbiology, immunology, gastroenterology, and molecular biology. Conclusion: This study systematically mapped the knowledge structure and evolutionary trends of global CeD-gut microbiota research. The findings indicate that research attention has expanded from early descriptive analyses of microbial composition toward functional and immune-related questions involving the gut microbiota-gluten peptide metabolism-epithelial barrier-mucosal immunity axis, which may provide a useful conceptual framework for interpreting the evolution of the literature. Future studies should further integrate prospective cohorts, multi-site sampling, multi-omics analyses, standardized dietary assessment, and immune phenotyping to investigate causal host-microbe relationships and evaluate the potential of microbiota-targeted nutritional and immunological strategies in CeD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.