Evidence map›Paper›PMID 42643431›Full record

ArticleFrontiers in immunology2026

Ecdysone signaling acts as a regulator of immunity and microbiota balance, shaping

Cecilia Stahl Vieira, Marco Salvemini, Petr Volf, Erich Loza Telleria

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cecilia Stahl VieiraDepartment of Parasitology, Faculty of Science, Charles University, Prague, Czechia.
Marco SalveminiDepartment of Biology, University of Naples Federico II, Naples, Italy.
Petr VolfDepartment of Parasitology, Faculty of Science, Charles University, Prague, Czechia.
Erich Loza TelleriaDepartment of Parasitology, Faculty of Science, Charles University, Prague, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The steroid hormone ecdysone, acting through its nuclear receptor (EcR), is a key regulator of insect development and reproduction and also contributes to immune regulation and gut microbiota homeostasis. In sand flies, both immunity and the gut microbiota are critical determinants for Methods: Using RNA interference-mediated silencing of EcR, we assessed how disruption of ecdysone signaling affects vector immunity, gut bacteria, and parasite development. Double-stranded RNA targeting EcR or a control sequence was microinjected into Results: Discussion: Collectively, our results indicate that ecdysone signaling regulates the Imd and JAK/STAT transcription factors, thereby modulating Conclusion: These findings identify ecdysone signaling as a central regulator coordinating immune responses and maintaining the balance between

Indexed as

EcdysoneGastrointestinal MicrobiomeLeishmania infantumLeishmaniasis, VisceralPhlebotomusSignal TransductionAnimalsFemaleInsect VectorsReceptors, SteroidRNA InterferenceEcdysoneecdysone receptorReceptors, Steroidantimicrobial peptides (AMPs)ecdysone signalingimmune signaling pathwaysLeishmania infantummicrobiotaPhlebotomus perniciosusRNA interference (gene silencing)sand flies

Identifiers

PMID42643431
PMCPMC13503605

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.