ArticleFrontiers in psychiatry2026
Reduced serum Klotho in chronic schizophrenia: diagnostic value and association with cognitive impairment.
Article in Frontiers in psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the correlation between serum Klotho levels and cognitive function in individuals with chronic Schizophrenia (SZ). Methods: A total of 108 patients diagnosed with chronic SZ and 83 age-matched healthy controls were recruited from four psychiatric specialist hospitals in Lianyungang from January to December 2024. Serum Klotho levels were measured using an enzyme-linked immunosorbent assay. Psychopathology and cognitive function were assessed using the Positive and Negative Syndrome Scale and the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), respectively. Kendall's tau-b correlation analyses were conducted to assess the associations between serum Klotho levels and cognitive function. Results: Compared with healthy controls, patients with SZ had significantly lower serum Klotho levels (233.61 ± 50.35 pg/mL Conclusion: Patients with chronic SZ have lower serum Klotho levels and show cognitive impairment, and Klotho levels are specifically associated with immediate memory in this population.
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