Evidence map›Paper›PMID 42643393›Full record

ArticleFrontiers in immunology2026

Photodynamic priming enhances anti-PD1 therapy responses in patient-derived pancreatic cancer organoid immune cocultures.

Pushpamali De Silva, Demi Wekking, Joanna Joeun Choe, Madeline D Kidd, Josie L Pearce, Dario Missael Rocha Castellanos, Piotr Zelga, Russell Jenkins, Kenneth K Wang, Vinay Chandrasekhara and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pushpamali De SilvaWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Demi WekkingWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Joanna Joeun ChoeWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Madeline D KiddWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Josie L PearceWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.
Dario Missael Rocha CastellanosDepartment of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, United States.
Piotr ZelgaDepartment of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, United States.
Russell JenkinsMassachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA, United States.
Kenneth K WangDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, United States.
Vinay ChandrasekharaDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Edward V MaytinDepartment of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, United States.
Andrew Scott LissDepartment of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, United States.
Tayyaba HasanWellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Funding

Small Molecule Enhancers of Photodynamic Therapy for Skin CancerP01CA084203 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Brian William Pogue · 2001 to 2026
$27.9M
Addressing Chemoresistance in Pancreatic and Ovarian Cancers: Photodynamic Priming and Repurposing of Tetracyclines using Targeted Photo-Activable Multi-Inhibitor LiposomeR01CA260340 · NCI · UNIV OF MARYLAND, COLLEGE PARK · PI HUANG, HUANG CHIAO · 2021 to 2025
$3.2M
Dual function theranostic constructs for photoacoustic guided surgery and photodynamic therapyR01CA231606 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HASAN, TAYYABA · 2019 to 2025
$3.1M
Molecular Imaging Guidance for Potentiating Chemoimmunotherapy in Pancreatic Cancer using Photodynamic PrimingR01EB034360 · NIBIB · UNIVERSITY OF TEXAS DALLAS · PI Girgis Obaid · 2024 to 2026
$1.6M
Epigenetic regulation of pancreatic cancer subtype identity and tumorigenesis by PHF2R01CA272876 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Andrew Liss · 2023 to 2026
$1.5M
NCI NIH HHS P01 CA084203NCI NIH HHS R01 CA231606NCI NIH HHS R01 CA260340NCI NIH HHS R01 CA272876NIBIB NIH HHS R01 EB034360
6 · The paper itself

Abstract

Photodynamic priming (PDP), a fallout of photodynamic therapy, transiently modulates the tumor microenvironment (TME), enhances therapeutic susceptibility, and promotes immunogenic cell death through the release of damage-associated molecular patterns (DAMPs). Pancreatic ductal adenocarcinoma (PDAC) remains non-responsive to current therapies with a desmoplastic and immunosuppressive TME that limits drug delivery and blunts responses to immune checkpoint blockade. We investigated whether PDP could enhance anti-PD1 therapy responses in PDAC using patient-derived organoids (PDOs). PDOs were treated with Visudyne and red light (25, 75, and 100 J/cm²), followed by assessment of cytotoxicity, DAMP expression (HSP60, calreticulin, HMGB1), and transcriptomic changes. Monocyte-derived dendritic cells (mDCs) from healthy donors were cocultured with PDP-treated (25 J/cm

Indexed as

Carcinoma, Pancreatic DuctalImmune Checkpoint InhibitorsPancreatic NeoplasmsPhotochemotherapyProgrammed Cell Death 1 ReceptorCoculture TechniquesDendritic CellsHumansLymphocyte ActivationTumor MicroenvironmentImmune Checkpoint InhibitorsPDCD1 protein, humanProgrammed Cell Death 1 Receptoradaptive immunityimmune checkpoint blockadeimmunogenic cell deathphotodynamic therapytumor resistance mechanisms

Identifiers

PMID42643393
PMCPMC13503572

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.