Evidence map›Paper›PMID 42643388›Full record

ArticleFrontiers in nutrition2026

From plant disease to protective agent: tea blister blight aqueous extract restore copper-induced oxidative and inflammatory damage in zebrafish model.

Jiaqi Liu, Nguyen Huy Hoang, Yuqing Ma, Song Tang, Haiyang Liu, Jiayan Long, Jiajia Zhang, Ren Mu, Xiaolu Zhou, Caibi Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiaqi Liu *Key Laboratory of National Forestry and Grassland Administration on Biodiversity Conservation in Southwest China, Yunnan Academy of Biodiversity, Key Laboratory of Forest Disaster Warning and Control in Yunnan Province, Ancient Tea Tree Research Center, College of Forestry, Southwest Forestry University, Kunming, China.
Nguyen Huy Hoang *College of Biological Science and Agriculture, Qiannan Normal University for Nationalities, Duyun, China.
Yuqing MaTea Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.
Song TangTea Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, China.
Haiyang LiuCollege of Biological Science and Agriculture, Qiannan Normal University for Nationalities, Duyun, China.
Jiayan LongKey Laboratory of National Forestry and Grassland Administration on Biodiversity Conservation in Southwest China, Yunnan Academy of Biodiversity, Key Laboratory of Forest Disaster Warning and Control in Yunnan Province, Ancient Tea Tree Research Center, College of Forestry, Southwest Forestry University, Kunming, China.
Jiajia ZhangCollege of Biological Science and Agriculture, Qiannan Normal University for Nationalities, Duyun, China.
Ren MuCollege of Biological Science and Agriculture, Qiannan Normal University for Nationalities, Duyun, China.
Xiaolu ZhouKey Laboratory of National Forestry and Grassland Administration on Biodiversity Conservation in Southwest China, Yunnan Academy of Biodiversity, Key Laboratory of Forest Disaster Warning and Control in Yunnan Province, Ancient Tea Tree Research Center, College of Forestry, Southwest Forestry University, Kunming, China.
Caibi ZhouKey Laboratory of National Forestry and Grassland Administration on Biodiversity Conservation in Southwest China, Yunnan Academy of Biodiversity, Key Laboratory of Forest Disaster Warning and Control in Yunnan Province, Ancient Tea Tree Research Center, College of Forestry, Southwest Forestry University, Kunming, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Oxidative stress and inflammation play key pathological mechanisms involved in the development of chronic diseases. Although tea blister blight reduces commercial tea quality, pathogen-induced stress may enhance the accumulation of bioactive phenolics and flavonoids, making infected leaves a potential resource for the food-medicine homology framework. This study aimed to evaluate the protective effects of a tea blister blight aqueous extract (TBB) against copper sulfate (CuSO Methods: Zebrafish embryos were exposed to 3 μM CuSO Results: TBB treatment significantly increased embryo survival by 12.74-15.81% and the hatching rate by 46.12-51.38% than the CuSO Conclusion: These findings demonstrate that TBB provides multilevel biological protection through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms. Importantly, this study provides a new perspective by demonstrating that tea leaves infected with tea blister blight disease, rather than being discarded or managed solely through fungicide application, can be valorized as a bioactive-enriched resource for applications in functional nutrition and health-promoting products.

Indexed as

antioxidantcopper sulfateinflammationtea blister blightzebrafish embryo

Identifiers

PMID42643388
PMCPMC13503560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.