ArticleFrontiers in cardiovascular medicine2026
Effects of transcutaneous auricular vagus nerve stimulation on cardiorespiratory fitness in patients with subacute stroke: a study protocol for a randomized controlled trial.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Patients with stroke often experience reduced cardiorespiratory fitness, which increases the risk of cardiovascular events, and conventional rehabilitation has limited efficacy in improving it. Transcutaneous auricular vagus nerve stimulation (taVNS) can modulate autonomic function, but its effect on cardiorespiratory fitness in stroke patients remains unclear. Methods: This randomized controlled trial will enroll 160 patients with subacute stroke, who will be randomly assigned in a 1:1 ratio to an experimental group or a control group. Both groups will receive conventional rehabilitation training. The experimental group will additionally receive active taVNS (left auricular concha, 25 Hz, 200 µs, intensity set at or slightly above the sensory threshold, 30 min/session, 5 sessions/week for 4 weeks), while the control group will receive sham stimulation (0 mA). The primary outcome is set as peak oxygen uptake (VO Discussion: This protocol aims to investigate the effect of taVNS on cardiorespiratory fitness in patients with subacute stroke.
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