Evidence map›Paper›PMID 42643338›Full record

ArticleFrontiers in medicine2026

Changing renal profile and early eGFR dynamics after ART initiation or switch in a large Italian HIV cohort.

Paolo Maggi, Manuela Ceccarelli, Elena Delfina Ricci, Giancarlo Orofino, Barbara Menzaghi, Nicola Squillace, Lucia Taramasso, Giuseppe Vittorio De Socio, Stefania Piconi, Giordano Madeddu and 4 more

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Paolo MaggiDepartment of Medicine and Surgery, "Kore" University of Enna, Enna, Italy.
Manuela CeccarelliDepartment of Medicine and Surgery, "Kore" University of Enna, Enna, Italy.
Elena Delfina RicciFondazione ASIA, Milan, Italy.
Giancarlo OrofinoDivision I of Infectious and Tropical Diseases, ASL Città di Torino, Turin, Italy.
Barbara MenzaghiUnit of Infectious Diseases, ASST della Valle Olona, Busto Arsizio, VA, Italy.
Nicola SquillaceInfectious Disease Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Lucia TaramassoInfectious Diseases Unit, IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.
Giuseppe Vittorio De SocioInfectious Diseases Clinic, Department of Medicine and Surgery, University of Perugia, Perugia, Italy.
Stefania PiconiUnit of Infectious Diseases, A. Manzoni Hospital, Lecco, Italy.
Giordano MadedduUnit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Giovanni Francesco PellicanòUnit of Infectious Diseases, Department of Clinical and Experimental Medicine, AOU Policlinico G. Martino, Messina, Italy.
Filippo LagiAOU Infectious and Tropical Diseases, Careggi Hospital, Florence, Italy.
Antonio Di BiagioInfectious Diseases Unit, IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy.
Paolo BonfantiInfectious Disease Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: To assess changes in renal profile over time and short-term estimated glomerular filtration rate (eGFR) after antiretroviral treatment (ART) initiation or switch in an Italian HIV cohort. Methods: We analyzed data from SCOLTA, a multicenter prospective pharmacovigilance cohort of people with HIV (PWH) initiating or switching ART in routine care. Participants enrolled between 2007 and 2024 with baseline eGFR ≥30 mL/min/1.73 m Results: Among 5170 participants, 25.7% were women and 18.2% were ART-naïve. Renal profile changed over time as the cohort became older and more treatment-experienced. The main decline in eGFR occurred during the first 24 weeks after ART initiation or switch, whereas changes from week 24 to week 48 were minimal. In adjusted analyses, ART-naïve participants showed a greater early decline in eGFR than ART-experienced individuals ( Conclusions: In PWH with baseline eGFR ≥30 mL/min/1.73 m

Indexed as

antiretroviral therapyestimated glomerular filtration rateHIVpharmacovigilancerenal function

Identifiers

PMID42643338
PMCPMC13503182

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