Evidence map›Paper›PMID 42643326›Full record

ArticleFrontiers in pediatrics2026

Outcomes and predictors of respiratory morbidity in children with neuromuscular disorders requiring respiratory support: a cohort study from Vietnam.

Hung Viet Dau, Tuoi Nguyen Thi, Lam Hoang Kim, Cuong Le Nhat, Canh Ngoc Hoang

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Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Hung Viet DauPediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam.
Tuoi Nguyen ThiDepartment of Pediatrics, University of Medicine and Pharmacy, Vietnam National University, Hanoi, Vietnam.
Lam Hoang KimPediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam.
Cuong Le NhatPediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam.
Canh Ngoc HoangPediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Respiratory failure is a major cause of intensive care admission in children with neuromuscular disorders, but data on outcomes and prognostic factors in mixed pediatric neuromuscular cohorts remain limited. This study aimed to describe short-term outcomes and identify predictors of poor outcomes in children with neuromuscular disorders requiring respiratory support in a tertiary pediatric intensive care unit. Methods: We conducted a single-center cohort study of children aged 1 month to 16 years with neuromuscular disorders requiring respiratory support admitted to a tertiary pediatric intensive care unit in Vietnam between January 2023 and June 2025. Poor outcome was defined as in-hospital mortality, invasive mechanical ventilation for ≥7 days, tracheostomy, or reintubation. Results: Sixty-three children were included. In-hospital mortality was 14.3% (9/63), and 33 children (52.4%) experienced a poor outcome. Nineteen children (30.2%) required invasive mechanical ventilation for ≥7 days, 10 (15.9%) underwent tracheostomy, and 20 (31.7%) required reintubation. Higher Pediatric Risk of Mortality III (PRISM III) score, shock, lower Glasgow Coma Scale score, and older age were independently associated with poor outcomes. Conclusions: Respiratory morbidity was substantial among children with neuromuscular disorders requiring respiratory support. Early illness severity and physiological instability at PICU admission were independently associated with poor outcomes.

Indexed as

mechanical ventilationneuromuscular disordersPediatric intensive careprognosisrespiratory failure

Identifiers

PMID42643326
PMCPMC13503341

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.