Evidence map›Paper›PMID 42643317›Full record

ArticleFrontiers in cellular and infection microbiology2026

Molecular characterization of mupirocin-resistant MRSA from Germany and South Africa.

Adebayo Osagie Shittu, Olga Perovic, Franziska Layer-Nicolaou, Birgit Strommenger, Tomiwa Olumide Adesoji, Taofiq Adewale Sulayman, Ayorinde Oluwatobiloba Afolayan, Alexander Mellmann, Frieder Schaumburg

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Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Adebayo Osagie ShittuInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.
Olga PerovicCentre for Healthcare-Associated Infections, Antimicrobial Resistance and Mycoses (CHARM) at National Institute for Communicable Diseases, a division of National Health Laboratory Service (NHLS), and University of Witwatersrand, Johannesburg, South Africa.
Franziska Layer-NicolaouNational Reference Centre (NRC) for Staphylococci and Enterococci, Division of Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany.
Birgit StrommengerNational Reference Centre (NRC) for Staphylococci and Enterococci, Division of Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch Institute, Wernigerode, Germany.
Tomiwa Olumide AdesojiDepartment of Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria.
Taofiq Adewale SulaymanDepartment of Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria.
Ayorinde Oluwatobiloba AfolayanLeibniz Institute-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
Alexander MellmannInstitute for Hygiene, University Hospital Münster, Münster, Germany.
Frieder SchaumburgInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methicillin-resistant Methods: Phenotypic identification of mupR-MRSA strains was verified by molecular methods. Characterization of all strains included PCR detection of Panton-Valentine leucocidin, immune evasion cluster genes, and staphylococcal protein A typing. Representative strains from each spa type were selected for whole-genome sequencing to determine their clonal lineages and relationships, including antibiotic and virulence gene content. Comparative analysis, phylogeny and classification of Results: Eighty-two mupR-MRSA were characterized, comprising 32 strains that exhibited high-level mupirocin resistance (HmupR) and 50 strains with low-level mupirocin resistance (LmupR). The plasmid-mediated Discussion: This study highlights the genetic diversity and potential for horizontal gene transfer among

Indexed as

Anti-Bacterial AgentsDrug Resistance, BacterialMethicillin-Resistant Staphylococcus aureusMupirocinStaphylococcal InfectionsBacterial ProteinsBacterial ToxinsExotoxinsGenetic VariationGermanyHumansLeukocidinsMicrobial Sensitivity TestsNuclear ProteinsPhylogenyPlasmidsAnti-Bacterial AgentsBacterial ProteinsBacterial ToxinsExotoxinsLeukocidinsmupA protein, Staphylococcus aureusMupirocinNuclear ProteinsPanton-Valentine leukocidinVirulence FactorsGermanyhigh-level mupirocin resistancelow-level mupirocin resistancemupA-plasmidsmupirocin-resistant methicillin-resistant Staphylococcus aureusSouth Africa

Identifiers

PMID42643317
PMCPMC13503169

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.