Evidence map›Paper›PMID 42643256›Full record

ArticleNeuroimage. Reports2026

Harnessing machine learning for functional connectivity-based feature discovery in post-traumatic epilepsy.

Alan Ho, Daniel J Valdivia, Henry Noren, Juliana Cantarutti, Pratik Jain, Taylor Zink, Koray Ercan, Karthik Narra, Christine Yohn, David M Scarisbrick and 3 more

Abstract read
In one paragraph

Article in Neuroimage. Reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Alan HoDepartment of Neurosurgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Daniel J ValdiviaDepartment of Neurosurgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Henry NorenDepartment of Neurosurgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Juliana CantaruttiDepartment of Neurosurgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Pratik JainDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Taylor ZinkDepartment of Neurosurgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Koray ErcanDepartment of Neurosurgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Karthik NarraDepartment of Neurosurgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Christine YohnDepartment of Neurosurgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
David M ScarisbrickDepartment of Neurosurgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Bharat BiswalDepartment of Biomedical Engineering, New Jersey Institute of Technology, Newark, NJ, USA.
Spencer ChenDepartment of Neurosurgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Hai SunDepartment of Neurosurgery, Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Funding

An Epileptic-Network Closed-loop Stimulation Device (enCLS) Designed to Target and Arrest IctogenesisR18NS141769 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Hai Sun · 2025 to 2026
$1.8M
NINDS NIH HHS R18 NS141769
6 · The paper itself

Abstract

•Leakage-free nested CV-RFE identifies a reproducible connectivity signature that characterizes the PTE-diseased state in our cohort.•Data-driven feature selection is essential for classification performance, with only four stable functional connections (from an original feature space of 4950) able to distinguish PTE from TBI with an AUC of 0.95.•We identify a specific connectivity phenotype in our PTE cohort which includes the Visual network as a hub of PTE-related changes, left-hemisphere overrepresentation and hyper-coupling, and right-hemisphere un-coupling.•The resting-state network disruptions identified by our ML paradigm went unrecognized by direct comparison between groups and traditional statistics, supporting the use of advanced data-driven methodologies for exploring functional connectivity in PTE.

Identifiers

PMID42643256
PMCPMC13503136

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.