ArticleExperimental biology and medicine (Maywood, N.J.)2026
The value of serum exosomal miRNA signature profiles for the early diagnosis of feline infectious peritonitis.
Article in Experimental biology and medicine (Maywood, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Feline Infectious Peritonitis (FIP) is a highly lethal disease in cats, and early differential diagnosis remains a significant clinical challenge. In this study, we analyzed differences in serum exosomal miRNA expression between FIP-affected cats and healthy control cats via high-throughput sequencing and identified five significantly differentially expressed miRNAs (miR-21-5p, miR-155-5p, miR-200c-3p, miR-486-5p, and miR-423-5p). A combined diagnostic model was constructed based on three key miRNAs (miR-21-5p, miR-155-5p, and miR-423-5p). ROC curve analysis showed that a combined model of these three key miRNAs had an area under the curve (AUC) of 0.93, with a sensitivity and specificity of 88.6% and 91.2%, respectively. These results indicate that the serum exosomal miRNA signature could be used as a novel biomarker for the early diagnosis of FIP, providing a non-invasive diagnostic tool in clinical practice.
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