ArticleFrontiers in neurology2026
AngioPLUS-derived carotid intraplaque neovascularization predicts recurrent anterior circulation stroke: a prospective cohort study.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose: The predictive value of carotid intraplaque neovascularization (IPN), assessed by the novel AngioPLUS technique, for recurrent anterior circulation ischemic stroke (ACIS) remains unclear. This study aimed to evaluate the prognostic value of IPN for stroke recurrence in patients with ACIS and to develop a parsimonious prediction model by screening core predictors using Lasso regression, with subsequent assessment of its discrimination, calibration, and clinical utility. Methods: Consecutive patients admitted for ACIS who underwent IPN assessment using AngioPLUS ultrasound between August 2020 and February 2025 were prospectively enrolled. Independent predictors of recurrent ischemic stroke were identified using Cox proportional hazards regression models. Least absolute shrinkage and selection operator (Lasso) regression was employed to screen core predictors for constructing a parsimonious Cox model. Model discrimination was evaluated using time-dependent receiver operating characteristic (ROC) curves, and internal validation was performed with Bootstrap resampling Results: A total of 143 patients (93 males, 65.0%; mean age 67.6 ± 11.7 years) with a median follow-up of 21 months (range 6-56 months) were enrolled, during which 26 patients experienced recurrent ischemic stroke. The recurrence rate was significantly higher in the high IPN group compared to the low IPN group (35.0% vs. 6.0%, Conclusion: Carotid IPN is an independent predictor of ACIS recurrence. A parsimonious Cox model incorporating IPN Grades 2 and LDL-C demonstrated favorable discrimination and calibration. The nomogram based on this model effectively identifies individuals at high risk of recurrence, offering a simple and practical tool for guiding individualized secondary prevention strategies in clinical practice.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.