ArticleFrontiers in nutrition2026
Dietary and lifestyle oxidative balance, metabolic dysfunction, and preserved ratio impaired spirometry in Chinese adults: a hospital-based cross-sectional study.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Preserved ratio impaired spirometry (PRISm) is a clinically relevant lung-function phenotype associated with adverse respiratory and systemic outcomes. Oxidative imbalance and metabolic dysfunction may contribute to impaired pulmonary reserve, but evidence from Chinese health examination populations remains limited. We examined the associations of oxidative balance score (OBS) and metabolic dysfunction indices with PRISm in Chinese adults. Methods: This hospital-based cross-sectional study included 1,311 adults undergoing routine health examinations between June 2024 and December 2025. PRISm was defined as FEV1/FVC ≥ 0.70 and FEV1 < 80% predicted. The standardized weighted OBS was constructed from dietary and lifestyle antioxidant/pro-oxidant components, and TyG, LAP, and AIP were analyzed as standardized continuous variables and quartiles. Multivariable logistic regression, restricted cubic splines, exploratory mediation analysis, and five-fold cross-validated machine-learning models were applied. Results: PRISm was identified in 92 participants (7.02%). The cohort mean (SD) values were 22.69 (4.98) for OBS, 8.69 (0.40) for TyG, 33.01 (16.73) for LAP, and 0.05 (0.36) for AIP. In fully adjusted models, higher OBS was associated with lower odds of PRISm (OR per 1-SD increase, 0.61; 95% CI, 0.48-0.77), whereas TyG, LAP, and AIP were positively associated with PRISm, with ORs of 1.52, 1.23, and 1.36, respectively. Restricted cubic splines showed an approximately linear inverse OBS-PRISm association. Higher OBS was also associated with more favorable metabolic profiles. Exploratory pathway analyses showed directionally consistent but statistically non-definitive indirect-effect estimates through metabolic indices. Machine-learning analyses showed modest discrimination and ranked TyG, OBS, LAP, and AIP among the leading predictors. Conclusion: Favorable oxidative balance was independently associated with lower PRISm probability, whereas metabolic dysfunction indices were associated with higher PRISm probability. These findings support an oxidative-metabolic profile associated with early lung-function impairment, while longitudinal studies are needed to clarify temporality and causality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.