Hydrogel microneedles loaded with engineered extracellular vesicles accelerate diabetic wound healing by promoting angiogenesis and modulating macrophage polarization.

Shaoyihan Fang, Jingjie Min, Zhenzhen Chen, Shuangyan Li, Yulu Zhou, Jingwen An, Zhongyi Chen, Dewu Liu

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Shaoyihan FangMedical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.

Jingjie MinMedical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.

Zhenzhen ChenOutpatient Department, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, China.

Shuangyan LiDepartment of Critical Care Medicine, Ezhou Central Hospital, Ezhou, Hubei, 436000, China.

Yulu ZhouFPRS Department/ENT Institute, Eye and ENT Hospital, Fudan University, Shanghai, China.

Jingwen AnMedical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.

Zhongyi ChenMedical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.

Dewu LiuMedical Center of Burn Plastic and Wound Repair, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330031, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress, impaired angiogenesis, and persistent inflammation contribute to delayed diabetic wound healing. In this study, ALDH2-loaded liposomes were associated with extracellular vesicles derived from human amniotic mesenchymal stem cells to generate an ALDH2@Lipo/EV hybrid formulation, which possess pro-angiogenic, antioxidant, and anti-inflammatory properties that modulate mitochondrial homeostasis in cells within diabetic wounds. To enhance the penetration efficiency of EVs in the wound, ALDH2@Lipo/EV were loaded into methacrylated gelatin (GelMA) hydrogel to fabricate the ALDH2@Lipo/EV-MN patch system. The microneedles technology enabled precise and efficient delivery of ALDH2@Lipo/EV, ensuring an optimal depth of delivery for maximum therapeutic efficacy. Mechanistically, ALDH2@Lipo/EV promoted angiogenesis

Indexed as

Diabetic wound healingEngineered extracellular vesiclesMesenchymal stem cell-derived extracellular vesiclesMicroneedles

Identifiers

PMID42643175

DOI10.1016/j.mtbio.2026.103555

PMCPMC13503132

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.