Evidence map›Paper›PMID 42642923›Full record

ArticleThe veterinary quarterly2026

LNC_003296 regulates the proliferation and differentiation of ovine myoblasts by modulating the stability of Hsp70.

Yize Song, Xiaofei Guo, Xiaosheng Zhang, Jinlong Zhang, Hui Sheng, Mingxing Chu

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PubMed Full text at PMC Publisher
In one paragraph

Article in The veterinary quarterly, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yize SongState Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
Xiaofei GuoTianjin Key Laboratory of Animal Molecular Breeding and Biotechnology, Tianjin Engineering Research Center of Animal Healthy Farming, Institute of Animal Science and Veterinary, Tianjin Academy of Agricultural Sciences, Tianjin, China.
Xiaosheng ZhangTianjin Key Laboratory of Animal Molecular Breeding and Biotechnology, Tianjin Engineering Research Center of Animal Healthy Farming, Institute of Animal Science and Veterinary, Tianjin Academy of Agricultural Sciences, Tianjin, China.
Jinlong ZhangTianjin Key Laboratory of Animal Molecular Breeding and Biotechnology, Tianjin Engineering Research Center of Animal Healthy Farming, Institute of Animal Science and Veterinary, Tianjin Academy of Agricultural Sciences, Tianjin, China.
Hui ShengTianjin Key Laboratory of Animal Molecular Breeding and Biotechnology, Tianjin Engineering Research Center of Animal Healthy Farming, Institute of Animal Science and Veterinary, Tianjin Academy of Agricultural Sciences, Tianjin, China.
Mingxing ChuState Key Laboratory of Animal Biotech Breeding, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are involved in various regulatory processes during muscle development. Our previous RNA-seq study identified LNC_003296 as being significantly differentially expressed between ovariectomized Small-tailed Han sheep (OR-STH) and their non-ovariectomized counterparts (STH). Through biotinylated RNA pull-down assays and RNA immunoprecipitation (RIP), we further demonstrated that LNC_003296 directly interacts with Hsp70. Protein stability and degradation experiments revealed that LNC_003296 enhances the protein stability of Hsp70. Overexpression of either LNC_003296 or Hsp70 promoted myoblast proliferation, facilitated differentiation, and contributed to skeletal muscle fiber formation. Conversely, their knockdown suppressed cell proliferation and inhibited differentiation. In summary, these data indicate that LNC_003296 can bind to Hsp70 and enhance its protein stability, thereby influencing the proliferation and differentiation of myoblasts.

Indexed as

Cell DifferentiationCell ProliferationHSP70 Heat-Shock ProteinsMyoblastsRNA, Long NoncodingAnimalsFemaleMuscle DevelopmentProtein StabilitySheepHSP70 Heat-Shock ProteinsRNA, Long NoncodingdifferentiationHsp70LNC_003296lncRNAmyoblastsprotein stabilitySheepskeletal muscle development

Identifiers

PMID42642923
PMCPMC13520862

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.