Evidence map›Paper›PMID 42642885›Full record

Trial reportPhysiological reports2026

A pilot randomized controlled trial of the effects of dietary nitrate supplementation on dynamic cerebral autoregulation in older adults with metabolic syndrome.

Jigar Gosalia, Jocelyn M Spicuzza, Christine Bowlus, Annabelle Brinkerhoff, Stephen R Baker, Juan Jan Qiu, Daniel B Kim-Shapiro, Jim A Pawelczyk, David N Proctor

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jigar GosaliaDepartment of Medicine, Division Renal Diseases and Hypertension, The University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.ORCID https://orcid.org/0000-0002-1378-230X
Jocelyn M SpicuzzaDepartment of Psychiatry, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-3183-0707
Christine BowlusDepartment of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania, USA.
Annabelle BrinkerhoffCollege of Medicine, The Pennsylvania State University, University Park, Pennsylvania, USA.
Stephen R BakerDepartment of Physics and Translational Science Center, Wake Forest University, Winston-Salem, North Carolina, USA.
Juan Jan QiuCollege of Medicine, The Pennsylvania State University, University Park, Pennsylvania, USA.
Daniel B Kim-ShapiroDepartment of Physics and Translational Science Center, Wake Forest University, Winston-Salem, North Carolina, USA.
Jim A PawelczykDepartment of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania, USA.
David N ProctorDepartment of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID https://orcid.org/0000-0002-4691-4575

Funding

Penn State Clinical and Translational Science InstituteUL1TR002014 · NCATS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KRASCHNEWSKI, JENNIFER L. · 2016 to 2025
$33.7M
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UL1 TR002014Huck Family Endowment for Nutritional Research in Family Medicine at Penn State College of Medicine and University ParkNCATS NIH HHS UL1 TR002014
6 · The paper itself

Abstract

Metabolic syndrome (MetS) is associated with reduced nitric oxide (NO) bioavailability and impaired cerebrovascular function, potentially increasing cognitive decline risk. Dynamic cerebral autoregulation (dCA) maintains cerebral blood flow and may involve NO-related vascular mechanisms. Whether dietary nitrate supplementation influences dCA in MetS remains unclear. This pilot trial evaluated feasibility and explored effects of nitrate supplementation on dCA. Twenty-two older adults with MetS (55-75 years) were randomized in a double-blind, placebo-controlled design to receive nitrate-rich beetroot juice (BRJ; 6.4 mmol NO

Indexed as

Cerebrovascular CirculationDietary SupplementsHomeostasisMetabolic SyndromeNitratesAgedDouble-Blind MethodFemaleFruit and Vegetable JuicesHumansMaleMiddle AgedPilot ProjectsNitratescerebral autoregulationcognitiondietary nitratefunctional near infrared spectroscopymetabolic syndrome

Identifiers

PMID42642885
PMCPMC13507522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.