Evidence map›Paper›PMID 42642712›Full record

ArticleChemMedChem2026

Design, Synthesis, and Structure-Activity Relationship Studies of Novel 3CL

Yixuan Feng, Feng Wang, Donglan Liu, Qiqi Yan, Leyuan Kang, Wenhao Zhao, Shixin Jin, Shuxiang Huang, Jincun Zhao, Ping Tian and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yixuan FengState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Feng WangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Donglan LiuState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health,  The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Qiqi YanState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Leyuan KangState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wenhao ZhaoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0009-0002-5308-1740
Shixin JinState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shuxiang HuangHealth and Quarantine Laboratory, Guangzhou Customs District Technology Center, Guangzhou, China.
Jincun ZhaoState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health,  The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Ping TianState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-5612-0664
Dingding GaoState Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-5368-6876

Funding

Expenditure Budget Program of Shanghai University of Traditional Chinese Medicine 24KFL035National Natural Science Foundation of China 22371188National Natural Science Foundation of China 22577078National Natural Science Foundation of China 82470003Science and Technology Commission of Shanghai Municipality 25ZR1401331Shanghai Frontiers Science Center for Traditional Chinese Medicine Chemical Biology, and Guangdong High-Level Talent Program 2025TQ09A487Shanghai Leading Talent Program of Eastern Talent LJ2024077Shanghai Municipal Health Commission 2024ZZ1010Shanghai PuJiang Programme 24PJD109State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine SHUTCM-SKL-202517
6 · The paper itself

Abstract

The SARS-CoV-2 3C-like protease (3CL

Indexed as

Antiviral AgentsCoronavirus 3C ProteasesCysteine Proteinase InhibitorsDrug DesignSARS-CoV-2A549 CellsDose-Response Relationship, DrugHumansMolecular Docking SimulationMolecular StructureStructure-Activity Relationship3C-like proteinase, SARS-CoV-2Antiviral AgentsCoronavirus 3C ProteasesCysteine Proteinase Inhibitorsantiviral activitiescatechol derivativescovalent inhibitorsSARS‐CoV‐2 3CLpro

Identifiers

PMID42642712
PMCPMC13506659

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.