Evidence map›Paper›PMID 42642709›Full record

ArticleDermatology and therapy2026

Emerald Touchless Sensor Quantifies Nighttime Scratching and Sleep Quality in Children With Atopic Dermatitis: PEDISTAD EMERALD Study.

Cory J Rubin, Lara W Lee, Amal Assa'ad, Irene Lara-Corrales, Dina Katabi, Hariharan Rahul, Siqiao Ruan, Pranav Krishna, Rumen Hristov, Karen J Chandross and 3 more

2 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Dermatology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03687359 active not recruitingnot on this map

Prospective, Observational, Longitudinal Study in Pediatric Patients With Moderate to Severe Atopic Dermatitis Whose Disease is Not Adequately Controlled With Topical Prescription Therapies or When Those Therapies Are Not Medically Advisable

Typeobservational_patient_registrySponsorSanofiRan2019 to 2035Enrolled1,860ConditionsDermatitis AtopicArmsStandard of care
NCT05235724 completednot on this map

Open-label 12-week Longitudinal Exploratory Study to Assess Reliability/Feasibility of Using Emerald Touchless Sensor for Scratching and Sleep Quantification in a Subset of PEDISTAD Patients

TypeobservationalSponsorSanofiRan2022 to 2023Enrolled18ConditionsDermatitis Atopic
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cory J RubinMichigan Dermatology Institute, Waterford, MI, USA.
Lara W LeeMedical University of South Carolina, Charleston, SC, USA.ORCID http://orcid.org/0000-0001-6739-4508
Amal Assa'adCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0001-7791-6859
Irene Lara-CorralesDivision of Dermatology, The Hospital for Sick Children, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-3210-3413
Dina KatabiEmerald Innovations, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4854-4157
Hariharan RahulEmerald Innovations, Cambridge, MA, USA.
Siqiao RuanEmerald Innovations, Cambridge, MA, USA.
Pranav KrishnaEmerald Innovations, Cambridge, MA, USA.
Rumen HristovEmerald Innovations, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6965-4016
Karen J ChandrossSanofi, Morristown, NJ, USA.
Rajan GuptaSanofi, 450 Water St, Cambridge, MA, 02141, USA.
Marius ArdeleanuRegeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
Annie ZhangSanofi, 450 Water St, Cambridge, MA, 02141, USA. Annie.Zhang@sanofi.com.

Funding

Sanofi Sanofi R&D iDEA-TECH Award
6 · The paper itself

Abstract

introductionIn children with atopic dermatitis (AD), itch-related nighttime scratching is associated with significant sleep disturbances. The aim of this study is to report the feasibility of using the Emerald touchless sensor to quantify nighttime scratching and sleep patterns in pediatric patients.

methodsPEDISTAD EMERALD (NCT05235724), an open-label, 12-week, exploratory study, included 20 pediatric patients with moderate-to-severe AD aged 6-11 years from the PEDISTAD registry (NCT03687359). The Emerald touchless sensor measures sleep onset and efficiency. Correlation analyses were performed between sleep onset and Peak Pruritus Numeric Rating Scale (PP-NRS), scratching events and time per hour and PP-NRS, and weekly averages of nightly scratching events per hour and sleep efficiency.

resultsWe show strong statistically significant correlations between sleep onset and PP-NRS (Pearson correlation coefficient: r = 0.50; p = 0.049) and between scratching events per hour and sleep efficiency (r = - 0.66; p = 0.003). Additionally, we observed positive correlations between scratching events (r = 0.46; p = 0.076) and scratching time per hour (r = 0.43; p = 0.096) and PP-NRS that did not reach statistical significance.

conclusionsThe Emerald touchless sensor can provide objective measures of itch-related scratching and sleep disturbance in children with AD in a home setting, demonstrating its feasibility for use in pediatric clinical trials.

trial registrationNCT05235724.

Indexed as

Atopic dermatitisEmerald sensorPediatricScratchingSleep

Identifiers

PMID42642709

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.