Evidence map›Paper›PMID 42642620›Full record

ArticleNature plants2026

Atypical E2F transcription factors couple Polycomb Repressive Complex 2 to endosperm cell division and differentiation.

Yongyan Wang, Dongsheng Shi, Yuhong Wei, Yuejiao Dong, Fengjiao Niu, Xiaoyue Luan, Xiaotian Zhang, Qingwen Shen, Hongyu Chen, Hua Jiang and 2 more

Erratum issuedAbstract read
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In one paragraph

Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Yongyan Wang *State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, CIMMYT-China Joint Center of Wheat and Maize, Center for Crop Genome Engineering, College of Agronomy, Henan Agricultural University, Zhengzhou, China.
Dongsheng Shi *School of Environmental and Rural Science, University of New England, Armidale, New South Wales, Australia.
Yuhong WeiState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, CIMMYT-China Joint Center of Wheat and Maize, Center for Crop Genome Engineering, College of Agronomy, Henan Agricultural University, Zhengzhou, China.
Yuejiao DongState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, CIMMYT-China Joint Center of Wheat and Maize, Center for Crop Genome Engineering, College of Agronomy, Henan Agricultural University, Zhengzhou, China.
Fengjiao NiuState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, CIMMYT-China Joint Center of Wheat and Maize, Center for Crop Genome Engineering, College of Agronomy, Henan Agricultural University, Zhengzhou, China.
Xiaoyue LuanState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, CIMMYT-China Joint Center of Wheat and Maize, Center for Crop Genome Engineering, College of Agronomy, Henan Agricultural University, Zhengzhou, China.
Xiaotian ZhangState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, CIMMYT-China Joint Center of Wheat and Maize, Center for Crop Genome Engineering, College of Agronomy, Henan Agricultural University, Zhengzhou, China.
Qingwen ShenState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, CIMMYT-China Joint Center of Wheat and Maize, Center for Crop Genome Engineering, College of Agronomy, Henan Agricultural University, Zhengzhou, China.
Hongyu ChenState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, CIMMYT-China Joint Center of Wheat and Maize, Center for Crop Genome Engineering, College of Agronomy, Henan Agricultural University, Zhengzhou, China.
Hua JiangInstitute for Biochemistry and Biology, University of Potsdam, Potsdam-Golm, Germany.ORCID http://orcid.org/0000-0002-7561-3085
Jihua TangState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, CIMMYT-China Joint Center of Wheat and Maize, Center for Crop Genome Engineering, College of Agronomy, Henan Agricultural University, Zhengzhou, China.
Guifeng WangState Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, CIMMYT-China Joint Center of Wheat and Maize, Center for Crop Genome Engineering, College of Agronomy, Henan Agricultural University, Zhengzhou, China. guifeng.wang@henau.edu.cn.ORCID http://orcid.org/0000-0002-5730-537X

Funding

Ministry of Science and Technology of the People's Republic of China (Chinese Ministry of Science and Technology) 2021YFF1000303National Natural Science Foundation of China (National Science Foundation of China) U22A20466 and 32472118Natural Science Foundation of Henan Province (Henan Province Natural Science Foundation) 232300421035
6 · The paper itself

Abstract

Flowering plant endosperm and mammalian placenta represent convergent evolutionary products sharing conserved developmental programmes, embryonic nutrient transport and genomic imprinting. Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 silencing restricts precocious tissue overproliferation in both lineages, yet the underlying molecular mechanism remains undefined. Here we show that mutations in ancestral maize ZmFIE2, not its derived paralogue ZmFIE1, abrogates global H3K27me3 levels, resulting in aberrant cell proliferation, impaired differentiation in early endosperm and seed lethality. ZmFIE2 physically interacts with the ancient atypical E2F transcription factor ZmE2F12 to recruit PRC2, depositing H3K27me3 at G1/S-phase and differentiation genes via E2F motifs in their promoters and repressing their expression. Codepletion of ZmE2F12 and its close paralogue ZmE2F13 abolishes this epigenetic repression and induces excessive endosperm cell proliferation. The orthologous DEL1-FIE complex functions equivalently in Arabidopsis endosperm. Collectively, our findings delineate a conserved E2F-PRC2 epigenetic module that restricts G1/S-phase progression to maintain endosperm developmental homeostasis.

Indexed as

Cell DivisionE2F Transcription FactorsEndospermPlant ProteinsPolycomb Repressive Complex 2Zea maysCell DifferentiationGene Expression Regulation, PlantE2F Transcription FactorsPlant ProteinsPolycomb Repressive Complex 2

Identifiers

PMID42642620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.