Evidence map›Paper›PMID 42642618›Full record

ArticleNature plants2026

A conserved hexapeptide switch controls autoinhibition of plant cytosolic invertases.

Yujie Fan, Chunyan Mo, Chuang Wang, Jianfeng Xing, Yunlong Zhang, Nan Sun, Qingbiao Xie, Yuan Yao, Kaiye Liu, Xue Yang and 12 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature plants, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Yujie Fan *State Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.ORCID http://orcid.org/0000-0003-1698-4158
Chunyan Mo *State Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.
Chuang WangState Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.
Jianfeng XingState Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.ORCID http://orcid.org/0000-0002-7356-6991
Yunlong ZhangState Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.
Nan SunState Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.
Qingbiao XieState Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.ORCID http://orcid.org/0000-0003-0666-4097
Yuan YaoState Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.ORCID http://orcid.org/0000-0002-9159-8671
Kaiye LiuState Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.ORCID http://orcid.org/0000-0003-2846-7609
Xue YangState Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.
Xiaodong LiuState Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.
Jun TaoState Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China.
Yongjun FangRubber Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.
Xiaohu XiaoRubber Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.
Zhendong ZhaoAnalytical & Testing Center, Center for Advanced Studies in Precision Instruments, Hainan University, Haikou, China.
Xueqing ZhouAnalytical & Testing Center, Center for Advanced Studies in Precision Instruments, Hainan University, Haikou, China.
Xiaolin TianCenter of Protein Analysis Technology, Tsinghua University, Beijing, China.
Haiteng DengCenter of Protein Analysis Technology, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0001-9496-1280
Jianquan LiuState Key Laboratory of Grassland Agro-ecosystem, College of Ecology, Lanzhou University, Lanzhou, China. liujq@nwipb.ac.cn.ORCID http://orcid.org/0000-0002-4237-7418
Zhenhua MingState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi Key Laboratory for Sugarcane Biology, Guangxi University, Nanning, China. zhming@gxu.edu.cn.ORCID http://orcid.org/0000-0003-0882-7216
Jiang WangState Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China. jiangwang@hainanu.edu.cn.ORCID http://orcid.org/0000-0002-0085-9056
Chaorong TangState Key Laboratory of Tropical Crop Breeding, Sanya Institute of Breeding and Multiplication, School of Tropical Agriculture and Forestry, Hainan University, Sanya, China. chaorongtang@126.com.ORCID http://orcid.org/0000-0001-9083-0531

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31825007
6 · The paper itself

Abstract

Cytosolic invertases (CINVs) are essential for plant sugar homeostasis, growth and development, yet their enzymatic regulation remains unclear. Here we show that land plant CINV enzymes are tightly autoinhibited via synergistic actions of their N- and C-termini on the central catalytic GH100 domain. A conserved C-terminal hexapeptide functions as a dual switch: an intrinsic 'brake' that inhibits GH100 and an 'accelerator' that recruits 14-3-3 activators upon phosphorylation. During plant terrestrialization, this motif evolved from 'TRSXpSW' to '[K/R]RSXpSW', enhancing both autoinhibition and 14-3-3 binding. In Hevea brasiliensis, 14-3-3-dependent CINV activation is the primary source of endogenous CINV enzyme activity in rubber-producing laticifers. In Arabidopsis thaliana, replacing its hexapeptide with ancestral variant relieves autoinhibition, elevates CINV activity and promotes growth. Our study unveils an evolutionarily refined, hexapeptide-mediated mechanism that controls CINV autoinhibition with potential for biotechnological crop improvement.

Indexed as

Arabidopsisbeta-FructofuranosidaseCytosolHeveaOligopeptidesPlant Proteins14-3-3 ProteinsAmino Acid Sequence14-3-3 Proteinsbeta-FructofuranosidaseOligopeptidesPlant Proteins

Identifiers

PMID42642618

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.