ArticleSports medicine - open2026
Cerebellar and Subcortical Connectivity Associated with Arthrogenic Muscle Inhibition After Acute ACL Rupture in Males: A Clinical and fMRI Study.
Article in Sports medicine - open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03950024 (Contribution of Functional Brain MRI to the Understanding of Arthrogenic Muscle Inhibition), which is not on this map. Not yet cited in PubMed.
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The trial behind it
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Contribution of Functional Brain MRI to the Understanding of Arthrogenic Muscle Inhibition (AMI) in the Aftermath of Knee Trauma.
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Authors and funding
9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundArthrogenic muscle inhibition (AMI) is a neurally mediated impairment of quadriceps activation following knee injury. Peripheral and spinal mechanisms are well described, but supraspinal contributions to AMI in the acute phase after injury remain underexplored.
objectiveTo investigate sensorimotor brain network connectivity changes associated with clinically classified AMI with task-based and resting-state functional magnetic resonance imaging (fMRI) in male patients with acute anterior cruciate ligament (ACL) rupture.
methodsIn this prospective comparative cohort study, 40 male patients (mean age 24.1 ± 2.9 years) with acute ACL injuries underwent resting-state and a motor imagery task-based functional magnetic resonance imaging (fMRI). Patients were classified into AMI (n = 20) and non-AMI (n = 20) groups based on clinical assessment using the SANTI classification system.
resultsThe average time from injury to scanning was 22.7 ± 7 days. Clinically, the AMI group presented with qualitative vastus medialis obliquus inhibition and more frequent extension deficit. Compared with the non-AMI group, the AMI group demonstrated significantly greater functional connectivity of the right cerebellar Crus 1 with several sensory and cognitive brain regions. Exploratory (not corrected for multiple comparisons) task-based analyses revealed greater activation in the right caudate nucleus and right thalamus during motor imagery of the involved limb in the AMI group.
conclusionMale patients with acute ACL rupture and clinically classified AMI using the SANTI classification presented more frequently with knee extension deficits and consistent vastus medialis obliquus inhibition than those without AMI. In these patients, AMI was associated with altered cerebellar connectivity and, on exploratory analysis, greater subcortical activation during motor imagery. These findings support a central neural contribution to AMI and identify cerebellar-subcortical pathways as candidate targets for future mechanistic and rehabilitation studies. Trial registration NCT03950024 (ClinicalTrials.gov) registered on May 9th, 2019.
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