Evidence map›Paper›PMID 42642533›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Regional cerebral blood flow correlates with transcriptional and cellular signatures in tinnitus.

Jixin Luan, Yue Chen, Aocai Yang, Manxi Xu, Hongwei Yu, Yuli Wang, Ni Shu, Gaoxiang Ouyang, Zhen Yuan, Guolin Ma

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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Jixin LuanDepartment of Radiology, China-Japan Friendship Hospital, No. 2 East Yinghua Road, Chaoyang District, Beijing, 100029, China.
Yue ChenDepartment of Radiology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Aocai YangDepartment of Radiology, China-Japan Friendship Hospital, No. 2 East Yinghua Road, Chaoyang District, Beijing, 100029, China.
Manxi XuDepartment of Radiology, China-Japan Friendship Hospital, No. 2 East Yinghua Road, Chaoyang District, Beijing, 100029, China.
Hongwei YuDepartment of Radiology, China-Japan Friendship Hospital, No. 2 East Yinghua Road, Chaoyang District, Beijing, 100029, China.
Yuli WangDepartment of Radiology, China-Japan Friendship Hospital, No. 2 East Yinghua Road, Chaoyang District, Beijing, 100029, China.
Ni ShuState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Gaoxiang OuyangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.
Zhen YuanFaculty of Health Sciences, University of Macau, Macau, SAR, China.
Guolin MaDepartment of Radiology, China-Japan Friendship Hospital, No. 2 East Yinghua Road, Chaoyang District, Beijing, 100029, China. maguolin1007@qq.com.ORCID http://orcid.org/0000-0002-4044-025X

Funding

the Macao Science and Technology Development Fund FDCT 0014/2024/RIB1the National Natural Science Foundation of China No. 82271953the National Natural Science Foundation of China No. U25A20136the STI2030-Major Projects No. 2022ZD0213300
6 · The paper itself

Abstract

purposeWe aimed to examine alterations of brain regional cerebral blood flow (CBF) in tinnitus patients using arterial spin labeling (ASL), and applied an integrative imaging-transcriptomics approach to explore the potential transcriptional and cellular correlates of these changes.

methodsParticipants included tinnitus patients (n = 56) and healthy controls (HCs) (n = 57). CBF images were acquired using an ASL sequence and analyzed. We used partial least square (PLS) regression to examine the spatial association between human brain gene expression (from the Allen Human Brain Atlas) and regional CBF changes in tinnitus. Bioinformatics and brain cell-type enrichment analyses were conducted using the genes that contributed significantly to the first PLS component.

resultsCompared with HCs, tinnitus patients exhibited increased CBF, primarily in the transverse temporal and superior temporal gyrus (p

conclusionOur findings identify spatial associations between genes, biological pathways, cell classes, and in vivo imaging correlates of tinnitus, particularly processes involving protein phosphorylation.

Indexed as

Arterial spin labelingCell typesRegional gene expressionTinnitusTranscriptomics

Identifiers

PMID42642533

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