Evidence map›Paper›PMID 42642521›Full record

ArticleNature aging2026

A geroprotective probiotic and its functional metabolite counteract inflammaging to extend healthspan.

Xiaoyong Lu, Jun Ping, Zichu Han, Shuo Zhang, Lixiao Liu, Muzhao Xiong, Yanling Fan, Jiaming Li, Xiaoyan Sun, Peng Yang and 19 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Xiaoyong Lu *Beijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0009-0007-6084-7376
Jun Ping *Quzhou Key Laboratory of Aging Biology and Longevity Medicine, Zhejiang-Germany Joint Laboratory on Lung Injury Repair and Regeneration, Department of Respiratory and Critical Care, Quzhou People's Hospital, Quzhou Affiliated Hospital Wenzhou Medical University, Quzhou, China.
Zichu Han *Beijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Shuo Zhang *Beijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Lixiao Liu *Beijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Muzhao Xiong *Beijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Yanling Fan *The First Affiliated Hospital, School of Basic Medical Sciences and Institute of Biomedical Innovation, Jiangxi Medical College, Nanchang University, Nanchang, China.
Jiaming Li *Beijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-2712-0064
Xiaoyan SunBeijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Peng YangBeijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Kejie ZhengLiver Transplant Center, Organ Transplant Center, West China Hospital of Sichuan University, Chengdu, China.
Zheng-Kai WangQuzhou Key Laboratory of Aging Biology and Longevity Medicine, Zhejiang-Germany Joint Laboratory on Lung Injury Repair and Regeneration, Department of Respiratory and Critical Care, Quzhou People's Hospital, Quzhou Affiliated Hospital Wenzhou Medical University, Quzhou, China.
Jiale PingBeijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Yu XiongQuzhou Key Laboratory of Aging Biology and Longevity Medicine, Zhejiang-Germany Joint Laboratory on Lung Injury Repair and Regeneration, Department of Respiratory and Critical Care, Quzhou People's Hospital, Quzhou Affiliated Hospital Wenzhou Medical University, Quzhou, China.
Yuesheng ZuoBeijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Min ZhangQuzhou Key Laboratory of Aging Biology and Longevity Medicine, Zhejiang-Germany Joint Laboratory on Lung Injury Repair and Regeneration, Department of Respiratory and Critical Care, Quzhou People's Hospital, Quzhou Affiliated Hospital Wenzhou Medical University, Quzhou, China.
Jingyi LiUniversity of Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-3126-7889
Qi WuQuzhou Key Laboratory of Aging Biology and Longevity Medicine, Zhejiang-Germany Joint Laboratory on Lung Injury Repair and Regeneration, Department of Respiratory and Critical Care, Quzhou People's Hospital, Quzhou Affiliated Hospital Wenzhou Medical University, Quzhou, China.
Qiaoran WangBeijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0003-1886-4854
Dan-Dan GaoQuzhou Key Laboratory of Aging Biology and Longevity Medicine, Zhejiang-Germany Joint Laboratory on Lung Injury Repair and Regeneration, Department of Respiratory and Critical Care, Quzhou People's Hospital, Quzhou Affiliated Hospital Wenzhou Medical University, Quzhou, China.
Beier JiangQuzhou Key Laboratory of Aging Biology and Longevity Medicine, Zhejiang-Germany Joint Laboratory on Lung Injury Repair and Regeneration, Department of Respiratory and Critical Care, Quzhou People's Hospital, Quzhou Affiliated Hospital Wenzhou Medical University, Quzhou, China.
Shuhui SunBeijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Shuai MaUniversity of Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-8858-4383
Si WangAging Biomarker Consortium (ABC), Beijing, China.ORCID http://orcid.org/0000-0003-2431-0612
Jing QuUniversity of Chinese Academy of Sciences, Beijing, China. qujing@ioz.ac.cn.ORCID http://orcid.org/0000-0002-3988-5067
Yun-Gui YangBeijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. ygyang@big.ac.cn.ORCID http://orcid.org/0000-0002-2821-8541
Feng ZhangQuzhou Key Laboratory of Aging Biology and Longevity Medicine, Zhejiang-Germany Joint Laboratory on Lung Injury Repair and Regeneration, Department of Respiratory and Critical Care, Quzhou People's Hospital, Quzhou Affiliated Hospital Wenzhou Medical University, Quzhou, China. fengzhang@wmu.edu.cn.ORCID http://orcid.org/0000-0002-6751-0377
Guang-Hui LiuUniversity of Chinese Academy of Sciences, Beijing, China. ghliu@ioz.ac.cn.ORCID http://orcid.org/0000-0001-9289-8177
Weiqi ZhangBeijing Key Laboratory of Intelligent Governance and Application of Biological Big Data, China National Center for Bioinformation and Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China. zhangwq@big.ac.cn.ORCID http://orcid.org/0000-0002-8885-5104

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiome profoundly influences host aging, yet the specific microbes and mechanisms governing divergent aging trajectories remain elusive. In this study, we delineated enterotype-specific gut microbial remodeling during aging and developed a microbiome-based aging clock (MicroAge) to track biological aging trajectories. We identified Bifidobacterium pseudocatenulatum (B. pseudocatenulatum) as a candidate geroprotective species consistently depleted during aging across both sexes and multiple Chinese cohorts. In naturally aged mice, oral B. pseudocatenulatum monotherapy rescued intestinal homeostasis, mitigated multiorgan inflammaging, enhanced cognitive-motor performance and extended healthspan. Mechanistically, we characterized 5-aminovaleric acid betaine (5-AVAB) as a key B. pseudocatenulatum-derived metabolite whose levels decline physiologically in aging humans. 5-AVAB supplementation partially recapitulated a broad spectrum of the systemic benefits observed with B. pseudocatenulatum treatment, including improved cognitive and motor function and suppressed multiorgan inflammaging. Our findings identify the B. pseudocatenulatum-5-AVAB axis as a promising target for microbiome-based interventions to promote healthy aging.

Indexed as

AgingBifidobacteriumGastrointestinal MicrobiomeInflammationLongevityProbioticsAnimalsCognitionFemaleHumansMaleMiceMice, Inbred C57BL

Identifiers

PMID42642521

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.