Evidence map›Paper›PMID 42642514›Full record

ArticleNature genetics2026

Predictive design of tissue-specific mammalian enhancers that function in the mouse embryo.

Shenzhi Chen, Vincent Loubiere, Ethan W Hollingsworth, Ken Murakami, Nikolaus Mandlburger, Sandra H Jacinto, Atrin Dizehchi, Jacob Schreiber, Evgeny Z Kvon, Alexander Stark

Abstract read
In one paragraph

Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Shenzhi Chen *Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0009-0004-2050-2873
Vincent Loubiere *Research Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0002-3632-378X
Ethan W HollingsworthDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-5188-3929
Ken MurakamiResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0003-0737-1288
Nikolaus MandlburgerResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0009-0006-0402-5418
Sandra H JacintoDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0001-9466-936X
Atrin DizehchiDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0009-0000-6382-2448
Jacob SchreiberResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0003-4230-6625
Evgeny Z KvonDepartment of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA.ORCID http://orcid.org/0000-0002-1562-0945
Alexander StarkResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria. stark@starklab.org.ORCID http://orcid.org/0000-0003-2611-0841

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Melanie Funes · 1994 to 2026
$57.9M
Deciphering the mechanism of long-range gene regulation in vivoDP2GM149555 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI KVON, EVGENY · 2022 to 2025
$2.4M
Decoding the Mechanism of Pathogenic Enhancer Mutations In Congenital Limb DisordersR01HD115268 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI Evgeny Kvon · 2024 to 2026
$1.2M
Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) DP2GM149555Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.) R01HD115268NCI NIH HHS P30 CA062203NICHD NIH HHS R01 HD115268NIGMS NIH HHS DP2 GM149555UC | UC Irvine | Chao Family Comprehensive Cancer Center (CFCCC) P30CA062203
6 · The paper itself

Abstract

Enhancers control tissue-specific gene expression across animals

Indexed as

Embryo, MammalianEnhancer Elements, GeneticAnimalsChromatinConvolutional Neural NetworksDeep LearningGene Expression Regulation, DevelopmentalHumansMiceOrgan SpecificityChromatin

Identifiers

PMID42642514
PMCPMC13553301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.