Evidence map›Paper›PMID 42642467›Full record

ArticleMolecular psychiatry2026

Dysregulation of local inhibitory inputs onto laterodorsal tegmental nucleus cholinergic neurons drives depression-like behaviors in mice.

Yaling Xu, Jun Du, Xia Li, Huapeng Diao, Lili Nie, Chao Yuan, Jiani Li, Yizheng Wang

Abstract read
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In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yaling Xu *Department of Neurology and National Research Center for Aging and Medicine and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
Jun Du *Institute for Translational Brain Research, Fudan University, Shanghai, China.
Xia LiThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.
Huapeng DiaoThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.
Lili NieThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.
Chao YuanThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China.
Jiani LiThe Brain Science Center, Beijing Institute of Basic Medical Sciences, Beijing, China. jianilifmmu@163.com.
Yizheng WangDepartment of Neurology and National Research Center for Aging and Medicine and National Center for Neurological Disorders, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China. yzwang@ion.ac.cn.ORCID http://orcid.org/0000-0003-4405-0029

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central cholinergic system plays a vital role in the pathogenesis of major depressive disorder. The cholinergic neurons in laterodorsal tegmental nucleus (LDTg) are the key components of the cholinergic system in brainstem. However, how the LDTg cholinergic neuronal activities are modulated in response to chronic stress remains largely unclear. We reported here that local inhibitory inputs from somatostatin-positive (SST

Identifiers

PMID42642467

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.