Real-time photoactivated SRS imaging enables spatiotemporally controlled nitroxyl release and therapeutic guidance in vivo.

Yi Wu, Liyang Ma, Jianpeng Ao, Hanzhang Chen, Kuan Luo, Ting Wang, Minbiao Ji, Xiaoyan Cui

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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Yi Wu *Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.

Liyang Ma *Department of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0007-8820-1403

Jianpeng AoDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai, China.

Hanzhang ChenDepartment of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China.

Kuan LuoDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai, China.

Ting WangShanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. wangting1983927@gmail.com.ORCID http://orcid.org/0000-0003-4334-6522

Minbiao JiDepartment of Radiology, Huadong Hospital, Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai Institute of Geriatrics and Gerontology, State Key Laboratory of Surface Physics and Department of Physics, Fudan University, Shanghai, China. minbiaoj@fudan.edu.cn.ORCID http://orcid.org/0000-0002-9066-4008

Xiaoyan CuiDepartment of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, China. xycui@chem.ecnu.edu.cn.ORCID http://orcid.org/0000-0001-6968-4701

Funding

National Natural Science Foundation of China (National Science Foundation of China) 22274056National Natural Science Foundation of China (National Science Foundation of China) 22374163National Natural Science Foundation of China (National Science Foundation of China) 22574055National Natural Science Foundation of China (National Science Foundation of China) 62425501

6 · The paper itself

Abstract

Quantitatively tracking the dynamics of reactive species in vivo with reliable spatiotemporal resolution is essential yet challenging, as it provides critical insights into physiological mechanisms, optimizes drug delivery, and advances precision medicine. Herein, leveraging stimulated Raman scattering (SRS) for in vivo quantification, this work develops a series of versatile photoactivable scaffolds that efficiently generate equivalent amounts of reactive nitroxyl (HNO) and cyano-azobenzene with high photoconversion efficiency (95.1%) and fast reaction dynamics (t

Indexed as

Nitrogen OxidesSpectrum Analysis, RamanAnimalsAzo CompoundsHumansKineticsZebrafishazobenzeneAzo CompoundsNitrogen Oxidesnitroxyl

Identifiers

PMID42642396

DOI10.1038/s41467-026-75717-y

PMCPMC13507050

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.