Evidence map›Paper›PMID 42642227›Full record

ArticleTobacco control2026

Measured and modelled nicotine emissions predict systemic nicotine exposure across sub-ohm and pod-based ENDS.

Soha Talih, Thomas Eissenberg, Mario El Hourani, Rola Salman, Rachel El Hage, Nareg Karaoghlanian, Wasim Maziak, Alan Shihadeh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tobacco control, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Soha TalihDepartment of Mechanical Engineering, American University of Beirut, Beirut, Lebanon.ORCID http://orcid.org/0000-0002-3520-675X
Thomas EissenbergDepartment of Psychology, Virginia Commonwealth University, Richmond, Virginia, USA.ORCID http://orcid.org/0000-0002-8277-5437
Mario El HouraniDepartment of Mechanical Engineering, American University of Beirut, Beirut, Lebanon.ORCID http://orcid.org/0000-0001-7176-6175
Rola SalmanDepartment of Mechanical Engineering, American University of Beirut, Beirut, Lebanon.
Rachel El HageDepartment of Mechanical Engineering, American University of Beirut, Beirut, Lebanon.
Nareg KaraoghlanianDepartment of Mechanical Engineering, American University of Beirut, Beirut, Lebanon.ORCID http://orcid.org/0000-0002-3553-7233
Wasim MaziakCollege of Public Health, Florida International University, Miami, Florida, USA.ORCID http://orcid.org/0000-0001-6126-8420
Alan ShihadehDepartment of Mechanical Engineering, American University of Beirut, Beirut, Lebanon as20@aub.edu.lb.ORCID http://orcid.org/0000-0001-6387-8564

Funding

Project 4: Using a prospective cohort survey to test population-level predictions generated by Projects 1-3U54DA036105 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI COBB, CAROLINE O · 2018 to 2022
$20.8M
Training and Education Core p270-287P50DA036105 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI EISSENBERG, THOMAS EVAN · 2013 to 2017
$19.2M
Nicotine flux, a potentially powerful tool for regulating nicotine delivery from electronic cigarettes: significance of nicotine flux to the rate of nicotine delivery and subjective effectsR01DA052565 · NIDA · AMERICAN UNIVERSITY OF BEIRUT · PI EL HELLANI, AHMAD, TALIH, SOHA · 2022 to 2024
$1.3M
Assessing the effect of nicotine reduction on ENDS user's addiction and exposuresR01DA053587 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI MAZIAK, WASIM · 2021 to 2023
$1.2M
NIDA NIH HHS P50 DA036105NIDA NIH HHS R01 DA052565NIDA NIH HHS R01 DA053587NIDA NIH HHS U54 DA036105
6 · The paper itself

Abstract

backgroundElectronic nicotine delivery systems (ENDS) can deliver nicotine at levels that rival or exceed cigarettes, shaping both smoking cessation outcomes and the emergence of nicotine dependence in previously nicotine-naïve users. We evaluated whether systemic nicotine exposure is associated with emitted nicotine dose measured in the laboratory and estimated from ENDS device physics.

methodsAcross two clinical studies, we compared plasma nicotine boost following ad libitum ENDS puffing sessions with nicotine doses derived by two complementary approaches: (1) analysis of nicotine content in puffing-machine-generated aerosols and (2) physics-based computer simulations.

resultsAcross both clinical datasets and three device types, plasma nicotine boost was associated with emitted nicotine dose measured in the laboratory (~40% of variance explained) and with that predicted by a first-principles model of coil heating and liquid vaporisation (~33%), despite not incorporating individual-participant physiological differences.

conclusionsThese results support a mechanistic link between ENDS device parameters and systemic nicotine exposure. Physics-based models may support prospective population-level evaluation of nicotine delivery, including for hypothetical products, for which emissions data are not yet available.

Indexed as

AddictionElectronic nicotine delivery devicesNicotine

Identifiers

PMID42642227
PMCPMC13600341

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.