Evidence map›Paper›PMID 42642207›Full record

ArticleInternational journal of spine surgery2026

Progression of Cervical Ossification of the Posterior Longitudinal Ligament: A Systematic Review and Meta-Analysis of Risk Factors, Surgical Approaches, and Reoperation Rates.

Sadegh Bagherzadeh, Mohsen Rostami, Faramarz Roohollahi, Morteza Faghih Jouibari, Gersham Rainone, Phillip M Johansen, Srujan Kopparapu, Patric Kim, Erik Hayman, Puya Alikhani

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Article in International journal of spine surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Sadegh Bagherzadeh *Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.ORCID http://orcid.org/0009-0000-1545-9218
Mohsen Rostami *Department of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA mohsenrostami@usf.edu.
Faramarz RoohollahiDepartment of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Morteza Faghih JouibariDepartment of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Gersham RainoneDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Phillip M JohansenDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Srujan KopparapuDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Patric KimDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Erik HaymanDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
Puya AlikhaniDepartment of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCervical ossification of the posterior longitudinal ligament (OPLL) frequently progresses despite decompression surgery, leading to recurrent myelopathy. This meta-analysis aims to quantify risk factors for OPLL progression, compare surgical strategies, and determine the pooled reoperation rate due to symptomatic progression.

methodsFollowing Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, 26 high-quality studies comprising 1929 patients were included. Standardized mean differences (SMDs) and odds ratios (ORs) with 95% confidence intervals were calculated to assess risk factors, and all of the analyses were done with a random-effects model. A network meta-analysis using a random-effects model was conducted to compare surgical approaches, utilizing laminoplasty (LP) as the reference node.

resultsSignificant demographic risk factors for OPLL progression included younger age (SMD: -0.68,

conclusionsOPLL progression is statistically predictable, driven by younger age, higher body mass index, reduced cervical range of motion, and mixed-type morphology. Because anterior and fusion procedures were associated with lower progression rates compared with LP, these approaches should be considered in high-risk patients; however, these findings should be interpreted with caution given the heterogeneity across included studies. CLINICAL RELEVANCE: For patients with high-risk profiles (eg, mixed-type OPLL), fusion or anterior decompression should be strongly considered over LP. When laminoplasty is used in high-risk patients, they should be advised on the necessity of long-term surveillance. LEVEL OF EVIDENCE: 3:

Indexed as

cervical myelopathycervical spinedisease progressionossification of the posterior longitudinal ligament (OPLL)systematic review and meta-analysis

Identifiers

PMID42642207
PMCPMC13670966

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.