Evidence map›Paper›PMID 42642181›Full record

ArticleGenes & development2026

MEIOSIN retains a STRA8-independent activity that contributes to meiotic gene activation across vertebrates.

Ryuki Shimada, Yukiko Imai, Kimi Araki, Toshihiro Kawasaki, Sakie Iisaka, Shingo Usuki, Kei-Ichiro Yasunaga, Sayoko Fujimura, Naoki Tani, Hitoshi Niwa and 3 more

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In one paragraph

Article in Genes & development, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ryuki ShimadaDepartment of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto 860-0811, Japan.ORCID http://orcid.org/0000-0001-6724-0875
Yukiko ImaiModel Fish Genetics Laboratory, Department of Gene Function and Phenomics, National Institute of Genetics (NIG), Mishima, Shizuoka 411-8540, Japan.ORCID http://orcid.org/0000-0002-4716-2563
Kimi ArakiInstitute of Resource Development and Analysis, Kumamoto University, Kumamoto 860-0811, Japan.ORCID http://orcid.org/0000-0002-1396-1527
Toshihiro KawasakiModel Fish Genetics Laboratory, Department of Gene Function and Phenomics, National Institute of Genetics (NIG), Mishima, Shizuoka 411-8540, Japan.ORCID http://orcid.org/0000-0002-6537-3284
Sakie IisakaDepartment of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto 860-0811, Japan.
Shingo UsukiLiaison Laboratory Research Promotion Center, IMEG, Kumamoto University, Kumamoto 860-0811, Japan.
Kei-Ichiro YasunagaLiaison Laboratory Research Promotion Center, IMEG, Kumamoto University, Kumamoto 860-0811, Japan.
Sayoko FujimuraLiaison Laboratory Research Promotion Center, IMEG, Kumamoto University, Kumamoto 860-0811, Japan.
Naoki TaniLiaison Laboratory Research Promotion Center, IMEG, Kumamoto University, Kumamoto 860-0811, Japan.
Hitoshi NiwaDepartment of Pluripotent Stem Cell Biology, IMEG, Kumamoto University, Kumamoto 860-0811, Japan.
Shigehiro KurakuMolecular Life History Laboratory, NIG, Mishima 411-8540, Japan.ORCID http://orcid.org/0000-0003-1464-8388
Noriyoshi SakaiModel Fish Genetics Laboratory, Department of Gene Function and Phenomics, National Institute of Genetics (NIG), Mishima, Shizuoka 411-8540, Japan.
Kei-Ichiro IshiguroDepartment of Chromosome Biology, Institute of Molecular Embryology and Genetics (IMEG), Kumamoto University, Kumamoto 860-0811, Japan; ishigurokei@chiba-u.jp.ORCID http://orcid.org/0000-0002-7515-1511

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meiotic entry in vertebrates has been viewed as a transcriptional switch driven by the MEIOSIN-STRA8 axis, but whether this represents the ancestral regulatory logic of meiosis has remained unclear. Here we combine comparative genomics with genetic and single-cell analyses in zebrafish and mice to show that MEIOSIN retains an intrinsic STRA8-independent activity. We identify

Indexed as

Adaptor Proteins, Signal TransducingMeiosisTranscriptional ActivationVertebratesZebrafish ProteinsAnimalsFemaleGene Expression Regulation, DevelopmentalMaleMiceOogenesisZebrafishAdaptor Proteins, Signal TransducingStra8 protein, mouseZebrafish Proteinsevolutiongerm cellmeiosismeiotic entryoocytescRNA-seqspermatocytetestistranscription factorzebrafish

Identifiers

PMID42642181
PMCPMC13637641

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.