Evidence map›Paper›PMID 42642079›Full record

Observational studyBMJ open2026

Prospective single-arm observational study evaluating a novel imaging device to assess anastomotic site mucosal oxygen tension and its association with anastomotic complications: study protocol.

Maryam Sherwani, Danish Ali, Phillip J Williams, Shannon McChesney, Molly M Ford, Alexander T Hawkins, Roberta Muldoon, Ben Hopkins, Timothy M Geiger, Aimal Khan

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07467980 (Anastomotic Site Mucosal Oxygen Tension and Its Association With Anastomotic Complications), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07467980 recruitingnot on this map

Anastomotic Site Mucosal Oxygen Tension and Its Association With Anastomotic Complications

TypeobservationalSponsorVanderbilt University Medical CenterRan2026 to 2028Enrolled80ConditionsAnastomotic Leak Rectum, Anastomotic Leak Large IntestineArmsA novel endoscopic imaging system that displays real-time oxygen saturation levels
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maryam SherwaniSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID http://orcid.org/0000-0002-0925-1848
Danish AliDepartment of Surgery, University of Texas Health Science Center, San Antonio, Texas, USA.
Phillip J WilliamsSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Shannon McChesneySection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Molly M FordSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Alexander T HawkinsSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Roberta MuldoonSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Ben HopkinsSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Timothy M GeigerSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Aimal KhanSection of Surgical Sciences, Vanderbilt University Medical Center, Nashville, Tennessee, USA aimal.khan@vumc.org.ORCID http://orcid.org/0000-0003-2851-8330

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnastomotic leaks and strictures remain major sources of morbidity following colorectal surgery, with perfusion failure playing an important role in their development. Although methods such as indocyanine green fluorescence angiography are widely used to assess intraoperative perfusion, they have notable limitations including a lack of quantitative measurement. Emerging imaging modalities capable of quantifying tissue oxygen saturation (StO METHODS AND ANALYSIS: This prospective, observational, single-arm study aims to enrol 80 adult patients undergoing colorectal anastomosis. Imaging for evaluation of mucosal oxygen saturation will be performed intraoperatively at eight predefined sites near the staple line, and postoperative outcomes will be collected through 30 days. The lowest value recorded will be used for data analysis. The primary outcome of this study will be to evaluate the association of mucosal StO ETHICS AND DISSEMINATION: This study was approved by the Vanderbilt University Medical Center institutional review board (IRB #250787). Results will be submitted for publication in a peer-reviewed journal. TRIAL REGISTRATION NUMBER: NCT07467980.

Indexed as

Anastomosis, SurgicalAnastomotic LeakColorectal Surgical ProceduresIntestinal MucosaOxygenOxygen SaturationAdultColonFemaleHumansMaleMiddle AgedProspective StudiesRectumResearch DesignOxygenCancerColorectal surgeryGastrointestinal imaging

Identifiers

PMID42642079
PMCPMC13536058

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.