Hypoxia-inducible factor 1-alpha inhibition mitigates inflammatory responses induced by H9N2 avian influenza virus.

Suying Zhu, Beibei Li, Yaqi Wang, Yuhan Tian, Jiayue Zhang, Hongshan Wang

Abstract read

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Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Suying ZhuCollege of Agriculture and Bioengineering, Heze University, Heze, China.ORCID 0009-0004-4965-3421

Beibei LiCollege of Agriculture and Bioengineering, Heze University, Heze, China.

Yaqi WangCollege of Agriculture and Bioengineering, Heze University, Heze, China.

Yuhan TianCollege of Agriculture and Bioengineering, Heze University, Heze, China.

Jiayue ZhangCollege of Agriculture and Bioengineering, Heze University, Heze, China.

Hongshan WangCollege of Agriculture and Bioengineering, Heze University, Heze, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

H9N2 avian influenza virus (AIV) poses significant threats to poultry and public health, with the potential to contribute to the emergence of more virulent influenza strains. Hypoxia-inducible factor 1-alpha (HIF-1α) plays a crucial role in viral pathogenesis, immune regulation, and inflammation, making it a promising target for therapeutic intervention. Here, we explored the involvement of HIF-1α in H9N2 AIV pathogenesis and associated inflammatory responses. Our data revealed that HIF-1α exacerbates inflammation induced by H9N2 AIV infection through its regulation of mitochondrial fitness. Additionally, we investigated Sotetsuflavone (Seo), a naturally derived flavonoid, for its potential to modulate inflammatory responses following H9N2 infection. Molecular docking coupled with surface plasmon resonance assays indicated that Seo exhibits robust binding affinity to HIF-1α, implying a direct inhibitory mechanism. Subsequent

Indexed as

Hypoxia-Inducible Factor 1, alpha SubunitInflammationInfluenza A Virus, H9N2 SubtypeInfluenza in BirdsAnimalsCell LineChickensCytokinesDogsFlavonesHumansMiceMolecular Docking SimulationSignal TransductionTumor Necrosis Factor-alphaCytokinesFlavonesHypoxia-Inducible Factor 1, alpha SubunitTumor Necrosis Factor-alphaH9N2 avian influenza virushypoxia-inducible factor 1-alphainflammationSotetsuflavone

Identifiers

PMID42641155

DOI10.1128/spectrum.02680-25

PMCPMC13689394

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.