ArticleStem cells translational medicine2026
Up to 19-year cryopreservation does not impair hematopoietic progenitor function in cord blood: a 1129-unit analysis from the largest Korean public cord blood bank.
Article in Stem cells translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundWhether umbilical cord blood (UCB) quality is maintained during decades of cryopreservation is critical for public banking policy. We analyzed post-thaw quality of 1129 UCB units cryopreserved for up to 19 years at Korea's largest public cord blood bank and examined implications for shelf-life policy.
methodsUCB units manually volume-reduced and cryopreserved between 2006 and 2025 underwent pre-transplant testing using their attached integral segments (median storage 6.5 years; range 16 days-19.0 years). Associations between storage duration and 19 quality indicators and 13 paired pre-/post-thaw complete blood count parameters were analyzed by Spearman correlation (ρ) before and after adjusting for era effects (processing and testing dates) to separate genuine storage effects from longitudinal analytical variation. Predictors of colony-forming unit (CFU) were ranked by univariate correlation and a Random Forest machine-learning model. Compliance with German/FACT-NetCord pre-transplant criteria was assessed.
resultsAssociations between storage duration and quality indicators were modest before adjustment (|ρ| ≤ 0.4) and were largely abolished once differences in testing era were taken into account: the storage-duration correlations for viable CD45+ and viable CD34+ both lost significance, as did CFU/CD34 + (P = .327). The post-thaw CD34+ count was the strongest predictor of CFU. Testing date, although ranked only seventh by simple correlation, rose to second in the Random Forest model, indicating an era effect not captured by pairwise analysis. The composite pre-transplant criteria pass rate was 96.2%, remaining above 93% across all storage bins.
conclusionsAfter up to 19 years of cryopreservation, per-CD34+ colony-forming capacity is preserved. A test-based shelf-life policy is more evidence-based than a predetermined expiration limit.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.