Evidence map›Paper›PMID 42641010›Full record

ArticleChemistry & biodiversity2026

Chemical Composition and Biological Activities of Geopropolis From Four Melipona Species From the Brazilian Atlantic Forest.

Ariane Pinheiro Cruz Bergamini, Antônio Domingos de Sousa Júnior, Flavia Vitorino de Araújo Porto, Iana Soares Pessoa, Thiago Antonio de Sousa Cutrim, Victor Paulo Mesquita Aragão, Victor da Rocha Fonseca, Wanderson Romão, Denise Coutinho Endringer, Rodrigo Scherer and 1 more

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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ariane Pinheiro Cruz BergaminiPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Vila Velha, Espirito Santo, Brazil.
Antônio Domingos de Sousa JúniorPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Vila Velha, Espirito Santo, Brazil.
Flavia Vitorino de Araújo PortoPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Vila Velha, Espirito Santo, Brazil.
Iana Soares PessoaPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Vila Velha, Espirito Santo, Brazil.
Thiago Antonio de Sousa CutrimPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Vila Velha, Espirito Santo, Brazil.
Victor Paulo Mesquita AragãoPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Vila Velha, Espirito Santo, Brazil.
Victor da Rocha FonsecaPetroleomics and Forensic Laboratory, Universidade Federal do Espírito Santo (UFES), Vitória, Espirito Santo, Brazil.
Wanderson RomãoPetroleomics and Forensic Laboratory, Universidade Federal do Espírito Santo (UFES), Vitória, Espirito Santo, Brazil.ORCID https://orcid.org/0000-0002-2254-6683
Denise Coutinho EndringerPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Vila Velha, Espirito Santo, Brazil.ORCID https://orcid.org/0000-0001-9396-2097
Rodrigo SchererPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Vila Velha, Espirito Santo, Brazil.
Marcio FronzaPrograma de Pós-Graduação em Ciências Farmacêuticas, Universidade Vila Velha, Vila Velha, Espirito Santo, Brazil.ORCID https://orcid.org/0000-0002-7316-8598

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 12015/2021-6Conselho Nacional de Desenvolvimento Científico e Tecnológico 312015/2021-6Conselho Nacional de Desenvolvimento Científico e Tecnológico TO527/2020Foundation for Research Support of Espírito Santo 2021-NBD7G-TO431/2021
6 · The paper itself

Abstract

Geopropolis, a complex material produced by stingless bees from plant resins and soil components, represents a chemically diverse and underexplored source of natural products. This study investigated the chemical composition and biological activities of geopropolis from four Melipona species collected in the Brazilian Atlantic Forest during the dry and rainy seasons. Hydroalcoholic extracts were quantified for total phenolics, flavonoids, tannins, and characterized by electrospray ionization Fourier transform ion cyclotron resonance mass spectrometry (ESI(-)-FT-ICR MS), allowing the tentative assignment of 56 compounds, mainly phenolic acids, flavonoids, and terpenoids. Antioxidant activity was evaluated using DPPH and ABTS assays, anti-inflammatory activity by measuring nitric oxide, superoxide anion, and TNF-α production in LPS-stimulated macrophages, and antifungal activity against selected pathogenic strains. The extracts exhibited significant interspecific variation in phenolic composition and antioxidant activity (p < 0.05), with Melipona bicolor showing the highest antioxidant capacity, reflected by the lowest DPPH and ABTS IC

Indexed as

Antifungal AgentsAnti-Inflammatory AgentsAntioxidantsAnimalsBeesBenzothiazolesBiphenyl CompoundsBrazilFlavonoidsForestsLipopolysaccharidesMacrophagesMiceMicrobial Sensitivity TestsNitric OxidePhenols1,1-diphenyl-2-picrylhydrazylAntifungal AgentsAnti-Inflammatory AgentsAntioxidantsBenzothiazolesBiphenyl CompoundsFlavonoidsLipopolysaccharidesNitric OxidePhenolsPicratesSulfonic AcidsSuperoxidesTumor Necrosis Factor-alphaantifungal agentsantioxidantsgeopropolismeliponastingless bees

Identifiers

PMID42641010
PMCPMC13506092

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.