Evidence map›Paper›PMID 42641004›Full record

ArticleChemistry & biodiversity2026

Synthesis of 4-Hydroxyacetophenone-Derived Bis-Schiff Bases as Potent Cholinesterase Inhibitors: In Vitro Evaluation, Molecular Docking, DFT, and ADMET Analysis.

Muhammad Daud, Zainab Zainab, Aftab Alam, Imtiaz Ahmad, Ahmed A Elhenawy, Abdul Latif, Mumtaz Ali, Syed Adnan Ali Shah, Syahrul Imran, Ashwag S Alanazi and 2 more

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Muhammad Daud *Department of Chemistry, University of Malakand, Dir Lower, Pakistan.
Zainab Zainab *College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang, China.ORCID https://orcid.org/0000-0002-8673-8561
Aftab AlamDepartment of Chemistry, Rawalpindi Women University, Rawalpindi, Pakistan.ORCID https://orcid.org/0000-0003-0475-2376
Imtiaz AhmadPrograma de Pós-Graduação em Bioquímica e Bioprospecção, Universidade Federal de Pelotas, Pelotas, RS, Brazil.ORCID https://orcid.org/0000-0002-9551-0323
Ahmed A ElhenawyChemistry Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.ORCID https://orcid.org/0000-0003-2893-0376
Abdul LatifDepartment of Chemistry, University of Malakand, Dir Lower, Pakistan.ORCID https://orcid.org/0000-0002-9047-7747
Mumtaz AliDepartment of Chemistry, University of Malakand, Dir Lower, Pakistan.
Syed Adnan Ali ShahDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam, Selangor, Malaysia.ORCID https://orcid.org/0000-0002-8142-5013
Syahrul ImranAtta-ur-Rahman Institute for Natural Product Discovery (AuRIns), Universiti Teknologi MARA Cawangan Selangor Kampus Puncak Alam, Bandar Puncak Alam, Selangor, Malaysia.
Ashwag S AlanaziDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0003-1042-8126
Mohammed M AlanaziDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0002-0483-8113
Manzoor AhmadDepartment of Chemistry, University of Malakand, Dir Lower, Pakistan.ORCID https://orcid.org/0000-0001-9736-5900

Funding

Princess Nourah Bint Abdulrahman University PNURSP2026R342
6 · The paper itself

Abstract

In this study, bis-Schiff base derivatives bearing 4-hydroxyacetophenone were synthesized and assessed for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities. In the series, compound (2i) was identified as the most promising inhibitor of AChE (IC

Indexed as

AcetophenonesCholinesterase InhibitorsDensity Functional TheoryMolecular Docking SimulationAcetylcholinesteraseAnimalsButyrylcholinesteraseDose-Response Relationship, DrugHumansMolecular StructureSchiff BasesStructure-Activity Relationship4-hydroxyacetophenoneAcetophenonesAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsSchiff Bases4‐hydroxyacetophenoneacetylcholinesterasebis‐Schiff basesbutyrylcholineserasedensity functional theorykineticsmolecular docking

Identifiers

PMID42641004
PMCPMC13506093

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.