ReviewPLoS pathogens2026
The long and winding road: On the endoplasmic reticulum of Plasmodium and implications for pathogenesis.
Review in PLoS pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
3 authors.
Funding
Abstract
As a eukaryote, Plasmodium, the causative agent of malaria, is reliant on its endoplasmic reticulum (ER) for survival. However, as a protozoan pathogen, Plasmodium has also adapted its ER to support its parasitic lifestyle. This Pearl focuses on the interplay between conserved ER functions in Plasmodium such as cell signaling, protein synthesis/secretion, lipid production, and cellular stress, and their contribution to parasite pathogenesis. We further summarize the current knowledge about the role of the ER in pathogenic processes such as motility, egress/invasion, host-cell remodeling, and transmission throughout the blood, liver, sexual, and mosquito stages. Collectively, we hope that discussing the Plasmodium ER as both a conserved cellular hub and a source of parasite-specific biology offers promising opportunities for antimalarial strategies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.