Evidence map›Paper›PMID 42640804›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Cannabinoid tolerance relies on CB

Alicia Álvaro-Blázquez, Rui S Rodrigues, Carlos Montero-Fernández, Marta Isasa, Astrid Cannich, Doriane Gisquet, Ignacio Rodríguez-Crespo, Luigi Bellocchio, Giovanni Marsicano, Carlos Costas-Insua and 1 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alicia Álvaro-BlázquezDepartment of Biochemistry and Molecular Biology, Instituto Universitario de Investigación Neuroquímica, Complutense University, Madrid 28040, Spain.ORCID 0009-0004-0632-9912
Rui S RodriguesNeurocentre Magendie, Institut National de la Santé et de la Recherche Médicale Unité 1215, University of Bordeaux, Bordeaux 33000, France.ORCID 0000-0002-9343-745X
Carlos Montero-FernándezDepartment of Biochemistry and Molecular Biology, Instituto Universitario de Investigación Neuroquímica, Complutense University, Madrid 28040, Spain.ORCID 0000-0003-1078-2678
Marta IsasaProteomics Unit, Spanish National Cancer Research Center, Madrid 28029, Spain.
Astrid CannichNeurocentre Magendie, Institut National de la Santé et de la Recherche Médicale Unité 1215, University of Bordeaux, Bordeaux 33000, France.
Doriane GisquetNeurocentre Magendie, Institut National de la Santé et de la Recherche Médicale Unité 1215, University of Bordeaux, Bordeaux 33000, France.
Ignacio Rodríguez-CrespoDepartment of Biochemistry and Molecular Biology, Instituto Universitario de Investigación Neuroquímica, Complutense University, Madrid 28040, Spain.
Luigi BellocchioNeurocentre Magendie, Institut National de la Santé et de la Recherche Médicale Unité 1215, University of Bordeaux, Bordeaux 33000, France.
Giovanni MarsicanoNeurocentre Magendie, Institut National de la Santé et de la Recherche Médicale Unité 1215, University of Bordeaux, Bordeaux 33000, France.ORCID 0000-0003-3804-1951
Carlos Costas-InsuaDepartment of Biochemistry and Molecular Biology, Instituto Universitario de Investigación Neuroquímica, Complutense University, Madrid 28040, Spain.ORCID 0000-0003-3446-6899
Manuel GuzmánDepartment of Biochemistry and Molecular Biology, Instituto Universitario de Investigación Neuroquímica, Complutense University, Madrid 28040, Spain.ORCID 0000-0001-7475-118X

Funding

EC | Horizon Europe | Excellent Science | HORIZON EUROPE Marie Sklodowska-Curie Actions (MSCA) 101150763Fundacion Canna 29/2024Fundacion Canna 47/2023Institut National de la Santé et de la Recherche Médicale (Inserm)Ministerio de Ciencia, Innovación y Universidades (MCIU) PID2021-125118OB-I00Ministerio de Ciencia, Innovación y Universidades (MCIU) PID2024-156496OB-I00 to M.G.
6 · The paper itself

Abstract

Cannabinoids, the active components of cannabis, exert numerous acute effects in the brain by engaging cannabinoid CB

Indexed as

CannabinoidsDrug ToleranceNedd4 Ubiquitin Protein LigasesReceptor, Cannabinoid, CB1UbiquitinationAnimalsHEK293 CellsHumansMiceNeuronsPhosphorylationProteasome Endopeptidase ComplexSignal TransductionCannabinoidsNedd4l protein, mouseNedd4 Ubiquitin Protein LigasesProteasome Endopeptidase ComplexReceptor, Cannabinoid, CB1cannabinoidCB1 receptordrug toleranceprotein ubiquitinationsynaptic transmission

Identifiers

PMID42640804
PMCPMC13535161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.