Evidence map›Paper›PMID 42640801›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Multidomain interaction governs the filamentous assembly of the dominant-negative DNMT3A R882H mutant.

Jianbin Chen, Jiuwei Lu, Zhixu Long, Sol Yoon, Megan Fukunaga, Jikui Song

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jianbin Chen *Department of Biochemistry, University of California, Riverside, CA 92521.
Jiuwei Lu *Department of Biochemistry, University of California, Riverside, CA 92521.ORCID 0000-0002-6478-4081
Zhixu LongDepartment of Biochemistry, University of California, Riverside, CA 92521.
Sol YoonDepartment of Biochemistry, University of California, Riverside, CA 92521.
Megan FukunagaDepartment of Biochemistry, University of California, Riverside, CA 92521.
Jikui SongDepartment of Biochemistry, University of California, Riverside, CA 92521.ORCID 0000-0002-4958-1032

Funding

WORK ORDER 126643 B539 EXPAND IC SUITE75N91019D00024 · NIAID · LEIDOS BIOMEDICAL RESEARCH, INC. · PI BRISCOE, LYNN · 2019 to 2025
$3932.6M
NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Mechanistic Insights into Mammalian DNA MethylationR35GM119721 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Jikui Song · 2016 to 2026
$5.3M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM119721NIGMS NIH HHS R35 GM119721NIGMS NIH HHS U24 GM129539NIH HHS 75N91019D00024
6 · The paper itself

Abstract

DNA methyltransferase DNMT3A-mediated de novo DNA methylation is important for proper regulation of gene expression and genomic stability in development. The DNMT3A R882H (DNMT3A

Indexed as

DNA (Cytosine-5-)-MethyltransferasesCryoelectron MicroscopyDNA MethylationDNA Methyltransferase 3AHumansModels, MolecularMutationProtein DomainsProtein MultimerizationDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanDNA methylationDNMT3ADNMT3A R882Hpolymerization

Identifiers

PMID42640801
PMCPMC13535186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.