Evidence map›Paper›PMID 42640513›Full record

ArticleNeurochemical research2026

Glutamatergic Projection from the Ventrolateral Periaqueductal Gray to the Parafascicular Nucleus of the Thalamus Contributes to the Modulation of Neuropathic Pain in Mice.

Dong-Ning Li, Yao-Hua Liu, Jia Li, Hui-Min Tian, Li-Ming Liu, Zi-Ang Li, Zhong-Yi Liu, Sha-Sha Tao, Jin Cheng, Tian-Yu Zhao and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Dong-Ning LiDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.
Yao-Hua LiuDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.ORCID http://orcid.org/0009-0007-2166-7137
Jia LiDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.
Hui-Min TianDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.
Li-Ming LiuDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.
Zi-Ang LiDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.
Zhong-Yi LiuDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.
Sha-Sha TaoDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.
Jin ChengDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.
Tian-Yu ZhaoDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.
Yu-Jing ChenDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.
Jia-Qi ZhuDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.
Fen-Sheng HuangDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China.
Liang LiDepartment of Human Anatomy, Baotou Medical College, Baotou, 014040, China. li_liang0402@126.com.
Fei LiDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China. lifeifmmu@163.com.ORCID http://orcid.org/0000-0001-7413-7702
Yun-Qing LiDepartment of Anatomy, Histology and Embryology and K. K. Leung Brain Research Centre, The Fourth Military Medical University, Xi'an, 710032, China. deptanat@fmmu.edu.cn.ORCID https://orcid.org/0000-0002-3707-3348

Funding

Brain Science and Brain-like Intelligence Technology - National Science and Technology Major Project 2021ZD0204403National Natural Science Foundation of China 82130034
6 · The paper itself

Abstract

Chronic pain is frequently accompanied by increased pain sensitivity and affective disturbances. The ventrolateral periaqueductal gray (vlPAG) and the parafascicular nucleus of the thalamus (PF) are key nodes in pain modulation. However, the functional role of the vlPAG-PF neural pathway remains poorly understood. In this study, we employed an integrative approach combining neuroanatomical tracing and chemogenetic techniques to investigate the role of the vlPAG

Indexed as

Glutamic AcidIntralaminar Thalamic NucleiNeuralgiaPeriaqueductal GrayAnimalsHyperalgesiaMaleMiceMice, Inbred C57BLNeural PathwaysNeuronsVesicular Glutamate Transport Protein 2Glutamic AcidSlc17a6 protein, mouseVesicular Glutamate Transport Protein 2Glutamatergic neuronNeuropathic painParafascicular nucleus of the thalamusVentrolateral periaqueductal gray

Identifiers

PMID42640513

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.