Evidence map›Paper›PMID 42640499›Full record

ArticleHistochemistry and cell biology2026

The potential of harmaline on triple negative breast cancer: harmaline-DNA interaction related apoptosis, anti-metastasis, and in silico analysis.

Srividya Subramanian, Sai Krishna Guguloth, Sankar Pajaniradje, Suhail Ahmad Bhat, Sathyapriya Chandramohan, A P Vishnumaya, Anjali Suresh Nair, V K Archana, Suci Subramanian, Rukkumani Rajagopalan

Abstract read
PubMed Publisher
In one paragraph

Article in Histochemistry and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Srividya SubramanianDepartment of Biochemistry and Molecular Biology, Pondicherry University, Kalapet, Puducherry, 605014, India.
Sai Krishna GugulothDepartment of Biochemistry and Molecular Biology, Pondicherry University, Kalapet, Puducherry, 605014, India.
Sankar PajaniradjeDepartment of Biochemistry and Molecular Biology, Pondicherry University, Kalapet, Puducherry, 605014, India.
Suhail Ahmad BhatDepartment of Biochemistry and Molecular Biology, Pondicherry University, Kalapet, Puducherry, 605014, India.
Sathyapriya ChandramohanDepartment of Biochemistry and Molecular Biology, Pondicherry University, Kalapet, Puducherry, 605014, India.
A P VishnumayaDepartment of Biochemistry and Molecular Biology, Pondicherry University, Kalapet, Puducherry, 605014, India.
Anjali Suresh NairDepartment of Biochemistry and Molecular Biology, Pondicherry University, Kalapet, Puducherry, 605014, India.
V K ArchanaDepartment of Biochemistry and Molecular Biology, Pondicherry University, Kalapet, Puducherry, 605014, India.
Suci SubramanianDepartment of Biochemistry and Molecular Biology, Pondicherry University, Kalapet, Puducherry, 605014, India.
Rukkumani RajagopalanDepartment of Biochemistry and Molecular Biology, Pondicherry University, Kalapet, Puducherry, 605014, India. rrlabs2011@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer, particularly triple-negative breast cancer (TNBC), remains a therapeutic challenge owing to limited targeted treatment options and high metastatic potential. This study aimed to investigate the in vitro and in silico anticancer effects of harmaline, a naturally occurring β-carboline alkaloid, against the MDA-MB-231 breast cancer cell line, focusing on its cytotoxic, apoptotic, DNA-binding, and protein interaction potential. Cytotoxicity assessment by MTT assay revealed a significant reduction in cell viability with an IC

Indexed as

Antineoplastic AgentsApoptosisDNAHarmalineTriple Negative Breast NeoplasmsCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorFemaleHumansMDA-MB-231 CellsMolecular Docking SimulationAntineoplastic AgentsDNAHarmalineApoptosisBreast cancerCell cycle arrestDNA-binding interactionHarmalineMolecular docking

Identifiers

PMID42640499

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.