ArticleDigestive diseases and sciences2026
Prevalence and Predictors of Folate Deficiency in Patients with Celiac Disease.
Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCeliac disease (CeD) causes small bowel villus atrophy and may contribute to folate deficiency through both malabsorption and folate-deficient gluten-free diets (GFD). We sought to determine the prevalence and predictors of folate deficiency among adults with CeD treated at a single tertiary referral center.
methodsIn this cross-sectional study, folate-deficient and non-deficient CeD patients were compared by age, sex, presentation type, villus atrophy severity at diagnosis and follow-up, prior malignancy, and concomitant autoimmune disease. All patients received routine counseling to follow a GFD, although adherence was not quantified.
resultsAmong 825 patients (73% female), 58 (7%) had folate deficiency. Mean age at folate measurement was 43 (SD=18) years. Mean interval from time of diagnosis to folate measurement in folate-deficient and non-deficient patients was 8 vs 9 years, respectively (p=0.357). Folate-deficient patients were younger at folate measurement and CeD diagnosis (37 vs 44 years and 28 vs 34 years; p=0.002 and p=0.018). Ulcerative colitis was more common (5.2% vs 0.3%, p=0.003), while hypothyroidism was less common (6.9% vs 19%, p=0.022) among folate-deficient patients.
conclusionFolate deficiency is common in treated CeD and was associated with younger age and concomitant ulcerative colitis. Persistent deficiency may be related to folate-deficient GFDs or persistent gluten-driven inflammation. Differences in mean age between folate-deficient and non-deficient groups may be related to differing supplement use behaviors. Further studies are needed to guide screening and supplementation strategies and determine utility of grain fortification.
Indexed as
Identifiers
42640443What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.