Evidence map›Paper›PMID 42640422›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8

Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Kaidi Chen *Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.ORCID https://orcid.org/0009-0001-8797-1373
Rong Chen *Jinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.
Wei Li *Academy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
Bin Song *Department of Hepatobiliary and Pancreatic Surgery, Changhai Hospital, Naval Medical University, Shanghai, People's Republic of China.
Ruiying ZhangSchool of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China.
Lewei DaiJinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.
Yuwei QiJinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.
Ruqian ChenJinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.
Yifan XuJinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.
Hangbin LiJinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.
Jingyi HuangJinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.
Fangping WuJinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.
Jianan PengJinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.
Xinyu WangJinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.
Yang XiongJinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.
Chaofeng MuJinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.
Guilin ChengAcademy of Chinese Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
Zhaoshen LiNational Key Laboratory of Immunity and Inflammation, National Clinical Research Center for Digestive Diseases, Shanghai Institute of Pancreatic Diseases, Changhai Clinical Research Unit, Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University / Changhai Hospital, Naval Medical University, Shanghai, People's Republic of China.
Shanming RuanDepartment of Medical Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Traditional Chinese Medicine), Hangzhou, Zhejiang, People's Republic of China.
Lei HuangNational Key Laboratory of Immunity and Inflammation, National Clinical Research Center for Digestive Diseases, Shanghai Institute of Pancreatic Diseases, Changhai Clinical Research Unit, Department of Gastroenterology, The First Affiliated Hospital of Naval Medical University / Changhai Hospital, Naval Medical University, Shanghai, People's Republic of China.ORCID https://orcid.org/0000-0002-4225-9200
Mancang GuJinhua Academy of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University, Jinhua, Zhejiang, People's Republic of China.ORCID https://orcid.org/0000-0003-3782-0988

Funding

General Scientific Research Project of Zhejiang Provincial Education Department 2025YKJ10General Scientific Research Project of Zhejiang Provincial Education Department Y202456442National Natural Science Foundation of China 81774011National Natural Science Foundation of China 82230018National Natural Science Foundation of China 82274364National Natural Science Foundation of China 82474338Zhejiang Province Natural Science Foundation LY19H280001Zhejiang Province Natural Science Foundation LZ23H290001Zhejiang Provincial "Three Rural Areas and Nine Parties Agricultural Science and Technology Collaborator Program" 2025SNJF075
6 · The paper itself

Abstract

Pancreatic adenocarcinoma (PAAD), characterized by an immunosuppressive tumor microenvironment (TME) and resistance to immunotherapy, exhibits a dismal prognosis further exacerbated by obesity. This study demonstrates the potent immunomodulatory and antitumor effects of coixenolide, a bioactive fatty acid ester from Coix lacryma-jobi L., particularly in obesity-associated PAAD. Utilizing high-fat diet (HFD)-fed mouse models, we found that coixenolide significantly inhibited tumor growth in HFD mice compared to control diet (CD) mice, correlating with enhanced intra-tumoral CD8

Indexed as

CD8+ T cellscoixenolideferroptosishigh‐fat dietlipid peroxidationobesity‐associated pancreatic adenocarcinomaS100A8/A9‐CD36 axistumor microenvironment‐based immunotherapy

Identifiers

PMID42640422
PMCPMC13505587

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.