Evidence map›Paper›PMID 42640393›Full record

ReviewMolecular biology reports2026

Molecular cartography of breast cancer: decoding genomes, heterogeneity and the tumor microenvironment for personalized targeted therapeutics.

Ashik Anil Mathew, Kannan Ramalingam, Diya Gibu, K P Muhammed Hashim, S Aravind Raj, Nijin Samuel Raju, H C Ujwal

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ashik Anil MathewDepartment of Pharmacy Practice, East Point College of Pharmacy, Bangalore, India. ashikanilmathew@gmail.com.ORCID http://orcid.org/0000-0003-0551-6834
Kannan RamalingamDepartment of Pharmacy Practice, East Point College of Pharmacy, Bangalore, India.ORCID http://orcid.org/0000-0002-7283-1597
Diya GibuDepartment of Biotechnology, SRM Institute of Science and Technology, Chennai, India.ORCID http://orcid.org/0009-0003-9006-0567
K P Muhammed HashimDepartment of Pharmacy Practice, East Point College of Pharmacy, Bangalore, India.
S Aravind RajDepartment of Medicine, Amrita Institute of Medical Sciences, Kochi, India.ORCID http://orcid.org/0009-0000-5228-148X
Nijin Samuel RajuDepartment of Pharmacy Practice, East Point College of Pharmacy, Bangalore, India.ORCID http://orcid.org/0009-0004-0832-1586
H C UjwalDepartment of Pharmacy Practice, East Point College of Pharmacy, Bangalore, India.ORCID http://orcid.org/0009-0000-9560-8489

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Breast cancer is a multi-stage disease that unfolds with the utmost complexity and heterogeneity of various cell types; thus, the unraveling of its molecular mechanisms is required to develop improved therapeutic strategies. This review tries to dissect the complex landscape related to changes in gene expression control dynamics in breast cancer. The large area of gene mutations is discussed, pointing out their important part in the pathogenesis of the disease. The article further explains the heterogeneity of tumors, unwinding the hormone receptor pathways responsible for the variability in disease presentation. We also conducted a thorough examination of the tumor microenvironment, uncovering the complex involvement of immune cells in both protecting against and promoting tumor growth. This analysis uncovered tactics employed by tumors to evade the immune system. All in all, this review has strong implications for the understanding of molecular mechanisms and subsequently provides a background for current improvements in targeted therapy. The use of illustrative figures aids in enhancing the understanding of the complex molecular mechanisms underlying breast cancer.

Indexed as

Breast NeoplasmsTumor MicroenvironmentAnimalsFemaleGene Expression Regulation, NeoplasticHumansMolecular Targeted TherapyMutationPrecision MedicineBreast cancerGene mutationHomologous recombinationHormone receptor pathwaysTumor heterogeneity

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.