ArticleEuropean archives of psychiatry and clinical neuroscience2026
Suicide attempts, white matter microstructure, and cognitive function in schizophrenia.
Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundWhite matter abnormalities are important for understanding schizophrenia and related behaviors. However, the relationship between a history of suicide attempts and alterations in white matter microstructure among individuals with schizophrenia, and its impact on neurocognition, remains unclear.
methodsThis study scanned 283 individuals diagnosed with schizophrenia and 189 healthy controls. Fractional anisotropy (FA) derived from diffusion tensor imaging is used to assess white matter microstructure. Neurocognitive performance was assessed using the MATRICS Consensus Cognitive Battery.
resultsCompared to healthy controls, schizophrenia patients with a history of suicide attempts showed widespread reductions in white matter FA across multiple brain regions (FDR-corrected p < 0.05). In uncorrected analyses, patients with a history of suicide attempts showed a significant lower FA in the external capsule (EC) (p = 0.033, Cohen's d = -0.26) compared to patients without such history; two-week suicidal ideation was also associated with lower FA in the inferior fronto-occipital fasciculus (p = 0.018, d = -0.29). After FDR correction, none remained significant (all adjusted p > 0.05). A significant interaction was observed between suicide‑attempt history and EC FA in relation to the social cognition T‑score (p for interaction = 0.022).
conclusionsContrary to prior findings in mood disorders, we did not observe robust white matter microstructural alterations associated with suicide attempts in schizophrenia. EC FA was significantly associated with social cognition performance only in patients without a history of suicide attempts.
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