Evidence map›Paper›PMID 42640285›Full record

ArticleJournal of neurology2026

Real-world Roche Elecsys

Vincenzo Criscuolo, Valerio Nicolella, Carmela Polito, Rosa Sirica, Mariano Fiorenza, Domenica Sorvillo, Ilaria Delle Cave, Antonio Carotenuto, Maria Petracca, Roberta Lanzillo and 4 more

Abstract readComparative StudyValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Vincenzo CriscuoloDepartment of Neuroscience, Reproductive Science and Odontostomatology, Federico II University of Naples, Naples, Italy.
Valerio NicolellaDepartment of Neuroscience, Reproductive Science and Odontostomatology, Federico II University of Naples, Naples, Italy.
Carmela PolitoDepartment of Translational Medical Sciences, Federico II University of Naples, Naples, Italy.
Rosa SiricaDepartment of Translational Medical Sciences, Federico II University of Naples, Naples, Italy.
Mariano FiorenzaDepartment of Translational Medical Sciences, Federico II University of Naples, Naples, Italy.
Domenica SorvilloDepartment of Translational Medical Sciences, Federico II University of Naples, Naples, Italy.
Ilaria Delle CaveDepartment of Neuroscience, Reproductive Science and Odontostomatology, Federico II University of Naples, Naples, Italy.
Antonio CarotenutoDepartment of Neuroscience, Reproductive Science and Odontostomatology, Federico II University of Naples, Naples, Italy.
Maria PetraccaDepartment of Human Neuroscience, Sapienza University of Rome, Rome, Italy.
Roberta LanzilloDepartment of Neuroscience, Reproductive Science and Odontostomatology, Federico II University of Naples, Naples, Italy.
Giuseppe CastaldoDepartment of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, Naples, Italy.
Vincenzo Brescia MorraDepartment of Neuroscience, Reproductive Science and Odontostomatology, Federico II University of Naples, Naples, Italy.
Daniela TerraccianoDepartment of Translational Medical Sciences, Federico II University of Naples, Naples, Italy.
Marcello MocciaMultiple Sclerosis Unit, Policlinico Federico II University Hospital, Naples, Italy. marcello.moccia@unina.it.ORCID http://orcid.org/0000-0003-2613-3090

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeurofilament light chain (NfL) reflects neuro-axonal injury in multiple sclerosis (MS), but method-dependent bias limits interchangeability across automated platforms. We assessed agreement between Roche Elecsys

methodsIn this retrospective real-world cohort (N=253), fasting EDTA plasma was analyzed in singlicate on Elecsys

resultsOn the raw scale, platforms were strongly correlated but showed poor agreement (Coeff 6.91, 95% CI 6.44-7.38; r=0.879; CCC=0.107, 95% CI 0.090-0.123). After conversion of both assay outputs to published Simoa-equivalent values, alignment improved (Coeff 1.03, 95% CI 0.96-1.10). We derived a directional Elecsys

conclusionsElecsys

Indexed as

Multiple SclerosisNeurofilament ProteinsAdultBiomarkersFemaleHumansMaleMiddle AgedRetrospective StudiesBiomarkersneurofilament protein LNeurofilament ProteinsAtellicaLumipulseMultiple SclerosisNeurofilament light chainPlatform

Identifiers

PMID42640285
PMCPMC13506593

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.