ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Uhrf1-Mediated PKM2 Degradation via Ubiquitination Alleviates Inflammation and Pyroptosis in Inflammatory Bowel Disease.
Juan Zhang, Xin-Rong Xu, Hui-Lin Zhang, Qi-Meng Zhu, Xin-Yuan Li, Xi-Peng Shang, Jing-Hui Du, Christophe Morisseau, Feng Qiu, Cheng-Peng Sun
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
Juan Zhang *School of Chinese Materia Medica, School of Medical Technology, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Xin-Rong Xu *School of Chinese Materia Medica, School of Medical Technology, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Hui-Lin Zhang *School of Chinese Materia Medica, School of Medical Technology, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Qi-Meng ZhuSchool of Chinese Materia Medica, School of Medical Technology, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Xin-Yuan LiSchool of Chinese Materia Medica, School of Medical Technology, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Xi-Peng ShangFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Jing-Hui DuFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.
Feng QiuSchool of Chinese Materia Medica, School of Medical Technology, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.ORCID https://orcid.org/0000-0001-5505-8670 Cheng-Peng SunSchool of Chinese Materia Medica, School of Medical Technology, Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People's Republic of China.ORCID https://orcid.org/0000-0001-6801-3439 Funding
National Natural Science Foundation of China 82574688Natural Science Foundation of Tianjin 25JCYBJC00620Young Faculty's Research and Innovation Capability Development in Tianjin 25JCJQJC00180Young Scientific and Technological Talents (Level Two) in Tianjin QN20230212
6 · The paper itselfAbstract
Inflammatory bowel disease (IBD) is characterized by chronic relapsing intestinal inflammation and closely associated with persistent inflammatory responses and impairment of the mucosal barrier integrity. In this work, we demonstrated that Th17/Treg immune imbalance drove inflammation and pyroptosis in IBD, as revealed by single-cell RNA sequencing, and pyruvate kinase M2 (PKM2) and ubiquitin-like with PHD and RING finger domains 1 (Uhrf1) displayed a negative correlation in IBD clinic samples. Target fishing analysis revealed that eupatolide (EPT) covalently bound to C165 of PKM2 with a dissociation constant (K
Indexed as
eupatolideInflammatory bowel diseaseInteractionPKM2Uhrf1
Identifiers
PMID42640159
PMCPMC13505462
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