Evidence map›Paper›PMID 42640138›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Microenvironment-Adaptive Scaffold Rejuvenates Peripheral Nerve Regeneration During Aging Via Dual Modulation of Ferroptotic Stimuli in Schwann Cells.

Ning Zhan, Lixin Tian, Lianjie Peng, Jingyu Zhang, Lining Lin, Xiaoting Zhang, Yaxian Luo, Zhichao Liu, Xinhua Yao, Mouyuan Sun and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ning Zhan *Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
Lixin Tian *State Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang Key Laboratory of Additive Manufacturing Technology and Equipment, School of Mechanical Engineering, Zhejiang University, Hangzhou, China.
Lianjie Peng *Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
Jingyu ZhangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
Lining LinStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
Xiaoting ZhangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
Yaxian LuoStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
Zhichao LiuStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.
Xinhua YaoState Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang Key Laboratory of Additive Manufacturing Technology and Equipment, School of Mechanical Engineering, Zhejiang University, Hangzhou, China.
Mouyuan SunStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.ORCID https://orcid.org/0000-0002-6377-7648
Yong HeState Key Laboratory of Fluid Power and Mechatronic Systems, School of Mechanical Engineering, Zhejiang Key Laboratory of Additive Manufacturing Technology and Equipment, School of Mechanical Engineering, Zhejiang University, Hangzhou, China.ORCID https://orcid.org/0000-0002-9099-0831
Mengfei YuStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.ORCID https://orcid.org/0000-0002-7700-4697
Huiming WangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, China.ORCID https://orcid.org/0000-0002-1131-7455

Funding

National Key Research and Development Program of China 2023YFB3813003National Natural Science Foundation of China 82430031Zhejiang Provincial Natural Science Foundation of China LRG25H140001
6 · The paper itself

Abstract

Repairing peripheral nerve injury remains a clinical challenge due to its limited regenerative capacity and the situation is further compounded with age. In this study, we identified the dysregulated repair program of Schwann cells (SCs) as a key feature of the aging-dependent impairment of nerve regeneration, mediated by dual influence of ferroptosis. The ferroptosis-stressor-rich microenvironment inhibits SC function in regenerating nerves. Moreover, the persistent intracellular ferroptosis stressor accumulation could accentuate senescence-associated secretory phenotype (SASP) expression in SCs, culminating in the disruption of redifferentiation trajectory and repair programs of SCs. Herein, a composite nerve conduit integrating microenvironment-responsive Ga-PTA nanoparticles and maxillofacial-derived mesenchymal stem cells (Mmscs) is developed by melt electrospinning writing (MEW). Mechanistically, Ga-PTA nanoparticles competitively inhibited excessive ferroptosis to establish a pro-regenerative niche. Meanwhile, Mmscs was induced to differentiate into SC-like cells which bypassed the redifferentiation impairment of resident SASP-expressing SCs, offering promising therapeutic strategies for peripheral nerve and other tissue injuries during aging.

Identifiers

PMID42640138
PMCPMC13505465

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.