Evidence map›Paper›PMID 42640115›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Iron-Tannic Acid Hydrogel Mediated Mild Photothermal Therapy Combined With Ferroptosis Enhances Anti-Tumor Immunity in Colorectal Cancer.

Yuan Zhu, Xi Yu, Tao Wang, Wanyi Liu, Chang Lu, Jiani Zhong, Yujie He, Wei Li, Kunxi Zhang, Peihao Yin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuan ZhuCentral Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xi YuCentral Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0009-0001-8998-0126
Tao WangCentral Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wanyi LiuCentral Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chang LuCentral Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0009-0008-3187-6167
Jiani ZhongCentral Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yujie HeCentral Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wei LiDepartment of General Surgery, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-3694-8621
Kunxi ZhangDepartment of Polymer Materials, School of Materials Science and Engineering, Shanghai University, Shanghai, China.ORCID https://orcid.org/0000-0002-6341-3182
Peihao YinCentral Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0009-0001-1496-1107
Zeting YuanCentral Laboratory, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-1780-2563

Funding

Clinical Specialized Disease Construction Project of Shanghai Putuo District Municipal Health Commission 2024tszb01East China Normal University-Shanghai Putuo District Central Hospital Collaborative Research Center for Translational Medicine ECNU-SPDH CCTM-202519Key Discipline Construction Project of Shanghai Municipal Health and Wellness System 2024ZDXK0044Key Discipline Construction Project of Shanghai Municipal Health and Wellness System 2024ZDXK0046National Nature Science Foundation of China 82574862Science and Technology Innovation Project of Shanghai Putuo District Health Commission ptkwws202505Science and Technology Innovation Project of Shanghai Putuo District Health Commission ptkwws202609Shanghai Eastern Talent Program QNWS2025099
6 · The paper itself

Abstract

Postoperative recurrence and metastasis are the primary causes of mortality in colorectal cancer (CRC). And its immunosuppressive tumor microenvironment (TME) often results in the poor response to immune checkpoint blockade (ICB). This study designed an injectable and adhesive tannic acid-iron hydrogel for locally mild photothermal therapy (PTT, ≤ 45°C) and ferroptosis to prevent the postoperative recurrence and metastasis in combination with programmed death ligand 1 (PD-L1) checkpoint blockade immunotherapy. First, this system was assembled from tannic acid (TA) and gelatin microspheres to form an injectable and adhesive hydrogel (Gel/TA). Subsequently, the metal-polyphenol network (MPNs) was introduced via Fe

Indexed as

colorectal cancerferroptosisimmunotherapyiron‐tannic acid hydrogelmild photothermal therapy

Identifiers

PMID42640115
PMCPMC13505463

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.