ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2026
Impact of Gestational Maternal SARS-CoV-2 Infection on Neonatal Inflammatory Biomarkers.
Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
problemSince the beginning of the pandemic, millions of pregnant women have been exposed to SARS-CoV-2, eliciting concerns about maternal and fetal sequelae. Yet, the impact of SARS-CoV-2 on the child's immune response remains largely unexplored. METHOD OF STUDY: Herein, we leverage 833 mother-infant dyads from a New York City-based pregnancy cohort to explore prospective associations between maternal gestational SARS-CoV-2 infection and inflammatory biomarkers in newborns. Of the mothers, 100 were infected with SARS-CoV-2 during pregnancy, as confirmed through self-report, antibody and/or PCR test results. We obtained 92 inflammatory biomarker levels in neonatal dried blood spots (DBS) using the Olink Target 96 Inflammation panel. An empirical Bayes method was used to fit linear regression models to assess the effects of maternal infection during pregnancy on neonatal inflammatory markers at birth. We also conducted stratified analyses by timing of infection in early (<20 weeks) versus late (≥20 weeks) gestation.
resultsHigher levels of 22 inflammatory biomarkers, including CD5, TNFSF14, CD8a, TGF-α, and CD244, were observed in neonates prenatally exposed to SARS-CoV-2 compared to unexposed neonates (p
conclusionOur results indicate that maternal SARS-CoV-2 infection during pregnancy influences inflammatory biomarkers in newborns, with the timing of infection playing a critical role in determining these immune profiles. Thus, this study emphasizes the need for further research and long-term follow-up to examine future health consequences for the child.
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