Evidence map›Paper›PMID 42639767›Full record

ArticleJournal of traditional Chinese medicine = Chung i tsa chih ying wen pan2026

Yigongsan decoction ameliorates anemia of chronic disease by attenuating mothers against decapentaplegic homolog-signal transducer and activator of transcription 3 interaction to regulate iron homeostasis.

Zheng Qin, Zhu Xiaoqin, H U Jie, B U Jingyang, J I Yuting, Jiang Yiling, Shi Ling, Zhang Aiping, W U Zhihao, X U Haitao and 3 more

Abstract read
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In one paragraph

Article in Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Zheng QinDepartment of Hematology, Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine (Baoshan Hospital, Shanghai University of Traditional Chinese Medicine), Shanghai201999, China.
Zhu XiaoqinDepartment of Hematology, Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai200021, China.
H U JieShanghai Huating Town Community Health Service Center, Shanghai201816, China.
B U JingyangDepartment of Hematology, Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine (Baoshan Hospital, Shanghai University of Traditional Chinese Medicine), Shanghai201999, China.
J I YutingDepartment of Hematology, Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine (Baoshan Hospital, Shanghai University of Traditional Chinese Medicine), Shanghai201999, China.
Jiang YilingDepartment of Hematology, Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine (Baoshan Hospital, Shanghai University of Traditional Chinese Medicine), Shanghai201999, China.
Shi LingDepartment of Hematology, Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine (Baoshan Hospital, Shanghai University of Traditional Chinese Medicine), Shanghai201999, China.
Zhang AipingDepartment of Hematology, Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine (Baoshan Hospital, Shanghai University of Traditional Chinese Medicine), Shanghai201999, China.
W U ZhihaoDepartment of Hematology, Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine (Baoshan Hospital, Shanghai University of Traditional Chinese Medicine), Shanghai201999, China.
X U HaitaoDepartment of Hematology, Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine (Baoshan Hospital, Shanghai University of Traditional Chinese Medicine), Shanghai201999, China.
Zhang RuifengDepartment of Hematology, Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine (Baoshan Hospital, Shanghai University of Traditional Chinese Medicine), Shanghai201999, China.
Yang YangDepartment of Science and Technology Experiment Center, Shanghai University of Traditional Chinese Medicine, Shanghai201203, China.
Luo MeihongDepartment of Hematology, Shanghai Baoshan Hospital of Integrated Traditional Chinese and Western Medicine (Baoshan Hospital, Shanghai University of Traditional Chinese Medicine), Shanghai201999, China.

Funding

Construction of Key Medical Science (Specialty) Department in Baoshan District BSZK-2023-Z01National Natural Science Foundation Youth Project: Mechanism Study of Yigongsan Decoction in Improving Iron Metabolism in Anemia of Chronic Disease by Regulating the Hepcidin-ferroportin Axis Through Activin B Competitive Binding to Bone Morphogenetic Protein Receptors 81804021Shanghai Key Discipline of Traditional Chinese Medicine (Clinical Type) Project shzyyzdxk-2024208The Shanghai Oriental Talent Youth Program: Mechanism Study of Yigongsan Decoction in Improving Anemia of Chronic Disease by Downregulating Hepcidin Antimicrobial Peptide Through Histone Modification-mediated Crosstalk of Mothers Against Decapentaplegic Homolog/Signal Transducer and Activator of Transcription 3 Signaling Pathways QNWS2024111
6 · The paper itself

Abstract

objectiveTo investigate how Yigongsan decoction (YGS) regulates iron metabolism in anemia of chronic disease (ACD) by modulating the hepcidin-ferroportin axis, with particular focus on crosstalk between the mothers against decapentaplegic homolog (SMAD) and signal transducer and activator of transcription 3 (STAT3) signaling pathways.

methods

resultsLPS-treated mice, YGS significantly decreased splenic iron content (

conclusionOur results suggest that YGS may alleviate ACD by attenuating the interaction between the SMAD and STAT3 pathways, which appears to lead to reduced STAT3 phosphorylation and hepcidin expression, thereby re-establishing iron homeostasis. This identifies YGS as a potential therapeutic agent targeting inflammation-induced iron dysregulation.

Indexed as

AnemiaDrugs, Chinese HerbalIronSmad ProteinsSTAT3 Transcription FactorAnimalsCation Transport ProteinsChronic DiseaseFerroportinHepcidinsHep G2 CellsHomeostasisHumansMaleMiceMice, Inbred C57BLCation Transport ProteinsDrugs, Chinese HerbalFerroportinHepcidinsIronSmad ProteinsSTAT3 Transcription Factoranemia of chronic diseasehepcidin-ferroportin axisphosphorylationSmad proteinsSTAT3 transcription factorYigongsan decoction

Identifiers

PMID42639767
PMCPMC13494873

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.